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人肝癌组织中CD34和血管内皮生长因子的表达及微血管密度的 …
引用本文:Ma J,Zhou X,Zhang T,Sun G,Meng K. 人肝癌组织中CD34和血管内皮生长因子的表达及微血管密度的 …[J]. 中华病理学杂志, 2000, 29(4): 248-251
作者姓名:Ma J  Zhou X  Zhang T  Sun G  Meng K
作者单位:南京军区南京总医院病理科
摘    要:目的 探讨CD34和血管内皮生长因子(VEGF)在人肝癌组织中的表达及微血管密度(MVD)的病理意义。方法 对30例人肝细胞肝癌9HCC)及相应癌旁组织,10例肝硬化,5例轻度慢性肝炎和4例正常肝组织,进行了CD34、VEGF免疫组织化学SP法检测,对CD34阳性血管进行MVD计数,对VEGF进行半定量计数,并结合肝癌的病理特征进行分析。结果 HCC组织中CD34呈广泛,窦隙状阳性表达,而在正常及

关 键 词:肝肿瘤 微血管密度 血管内皮生长因子 CD34

Clinicopathologic study of angiogenesis in human hepatocellular carcinoma
Ma J,Zhou X,Zhang T,Sun G,Meng K. Clinicopathologic study of angiogenesis in human hepatocellular carcinoma[J]. Chinese Journal of Pathology, 2000, 29(4): 248-251
Authors:Ma J  Zhou X  Zhang T  Sun G  Meng K
Affiliation:Department of Pathology, Nanjing Jinling Hospital, Nanjing 210002, China.
Abstract:OBJECTIVE: To study clinicopathologic significance of microvessel density (MVD) and the expression of vascular endothelial growth factor (VEGF) in human hepato-cellular carcinoma (HCC). METHODS: 30 HCC cases with neighboring noncancerous tissues, 10 liver cirrhosis cases, 5 mild chronic hepatitis cases and 4 normal liver tissue samples were stained with CD34, VEGF by immunohistochemistry method. Quantitation of sinusoid-like vessels and semi-quantitation of VEGF expression were performed and analyzed in conjunction with the clinico-pathological features of HCC. RESULTS: All HCC tissues showed diffuse CD34 expression and its site of distribution was somewhat corresponding to the original structure of sinusoid-like pattern, while CD34 was negative in the "sinusoid" regions of normal and chronic liver disease. Both MVD and VEGF were correlated to portal vein invasion of HCC, MVD was also correlated to the tumor size. The MVD of tumor less than 2 cm in diameter was significantly lower than that of tumors with a diameter of 2 similar 5 cm. The positive rate of VEGF in HCC was 83.3%. The expression of VEGF was also remarkable in the neighboring noncancerous tissues in which inflammatory cell infiltration was apparent. CONCLUSIONS: MVD and expression of VEGF were remarkably increased in HCC. Both were correlated with portal vein invasion. VEGF derived from tumor cells and noncancerous tissues may be associated with the angiogenesis of HCC.
Keywords:Liver Neoplasms  Neovascularization   pathologic  Endothelial growth factors  Antigens CD34  Diagnosis  differential
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