高温超导心磁图对冠心病诊断价值的初步探讨

目的初步探讨高温超导心磁图仪（HT—MCG）在冠心病（CHD）诊断中的临床应用价值。方法应用北京大学物理学院自主开发研制的四通道HT—MCG，分别对53例冠心病患者（冠状动脉造影显示至少一支冠状动脉主要分支狭窄≥70％）和31例非冠心病患者（冠状动脉造影检查无狭窄）进行心磁图检查。定量指标为：平均分级（ACTM）和异常磁图比率（RAM）。结果CHD组的ACTM（3．04±1．09）显著高于对照组（1．45±1．15）（P〈0．05）。CHD组的RAM为（67．83±24．65）％，对照组的RAM为（33．06±21．71）％，两组比较差异有统计学意义（P〈0．05）。53例冠心病患者中，MCG出现异常改变的患者为44例（83．O％），ECG出现心肌缺血改变（异常Q波及ST—T段改变）的患者24例（45．3％），超声心动图检出节段性室壁运动异常的患者21例（39．6％），HT-MCG对冠心病诊断的阳性率显著高于ECG及UCG（P〈O．05）。结论高温超导心磁图对冠心病具有较高的诊断价值，且优于ECG及UCG。

Preliminary approach of value of the high-temperature superconducting magnetocardiography in diagnosis of coronary heart disease

Objective To evaluate the clinical application of the high-temperature superconducting mag- netoeardiography （HT-MCG） in diagnosis of coronary hear disease （CHD） and compare HT-MCG with ECG and echoeardiagraphy. Methods HT-MCG measurements were performed in 53 patients with CHD（eoronary angiogra- phy showed at least one major branch of coronary artery stenosis ≥ 70% ） and 31 patients with no-CHD （coronary angiography negative） by 4-channel HT-MCG instrument produced by Institute of Physics of Peking University. Two quantitative parameters were measured： average classification of total maps （ACTM）, ratio of abnormal maps （RAM）. Results ACTM and RAM were much higher in CHD group than in control group 3.04±1.09 vs 1.45：1： 1.15, P〈0.05; （67.83±24.65）% vs （33.06±21.71）%, P〈0.05]. In 44 out of 53 CHD patients（83.0%）, MCG had abnormal mapping patterns. The resting ECG examination showed ischemic changes, such as an abnormal Q wave and ST-T change,in 24 patients （45.3%）. Echocardiography revealed abnormal left ventficular wall motion, asyner- gy in 21 patients（39.6%）. The diagnostic value of HT-MCG for the patients with CHD was much higher than ECG and echocardiography（P〈0.05 ）. Conclusion Our study showed that resting HT-MCG had higher diagnostic value than ECG and echocardiography in patients with CHD.