Incisional healing in rats treated with diethyl maleate |
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Authors: | R. Yavuzer Ö. Tascilar E. Tekin O. Latifoğlu G. Akyol A. Dursun F. Taneri |
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Affiliation: | (1) Department of Plastic and Reconstructive Surgery, Gazi University, Medical Faculty, Ankara, Turkey;(2) Department of General Surgery, Gazi University, Medical Faculty, Ankara, Turkey;(3) Department of Pathology, Gazi University, Medical Faculty, Ankara, Turkey;(4) Ziya Gökalp Caddesi No: 42/3, TR-06420 Kizilay, Ankara, Turkey |
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Abstract: | Diethyl maleate (DEM) which binds and thus depletes tissue glutathione levels was used to aggravate the injury and to determine its effect on incisional healing. A 5 cm dorsal midline skin incision was performed on 40 albino Wistar rats in two groups and then closed by interrupted sutures. Groups received 0.9% NaCl and DEM at a dosage of 1 mg/kg/day intraperitoneally for seven days, respectively. On postoperative days 7 and 14, histopathological assessment and tensile strengths were measured. The DEM treated group had a marked inflammation with poorly defined collagen formation and the tensile strength measurements revealed a significant decrease (p <0.001) on the 7t day. On the other hand, the first group showed better collagenization and a lesser degree of inflammation. However, on the 14th day, there was no noticeable histopathological difference between the two groups; but, tensile strength values of the second group were still lower (p <0.05). In this animal model, DEM postponed the healing process and reduced the tensile strength. |
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Keywords: | Wound healing Diethyl maleate Tensile strength |
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