| 表皮生长因子及受体与增生性玻璃体视网膜病变 |
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| 引用本文： | 张磊,孙晓东. 表皮生长因子及受体与增生性玻璃体视网膜病变[J]. 国际眼科杂志, 2009, 9(1): 132-134. DOI: 10.3969/j.issn.1672-5123.2009.01.045 |
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| 作者姓名： | 张磊 孙晓东 |
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| 作者单位： | 上海交通大学附属第一人民医院眼科,中国上海市,200080;上海交通大学附属第一人民医院眼科,中国上海市,200080 |
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| 基金项目： | 中国上海市科委浦江人才发展计划基金，中国上海市上海交通大学附属第一人民医院眼科资助项目 |
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| 摘 要： | 表皮生长因子(epidermal growth factor,EGF)与其受体(ep-idermal growth factor receptor,EGFR)结合后可通过特定的信号传导通路调节细胞的增生、迁移、粘附等活动。研究发现EGF/EGFR可诱导视网膜色素上皮(retinal pigmentepithelial,RPE)细胞增生、移行,从而促进增生性玻璃体视网膜病变(proliferative vitreoretinopathy,PVR)的发生发展。我们通过本文从EGF/EGFR的结构、功能、参与PVR形成的机制等方面进行综述,并展望拮抗EGF/EGFR信号传导通路的方法在治疗PVR上的应用前景。
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| 关 键 词： | 表皮生长因子及受体 增生性玻璃体视网膜病变 增生 迁移 |
EGF/EGFR and proliferative vitreoretinopathy |
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| Lei Zhang,Xiao-Dong Sun. EGF/EGFR and proliferative vitreoretinopathy[J]. International Eye Science, 2009, 9(1): 132-134. DOI: 10.3969/j.issn.1672-5123.2009.01.045 |
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| Authors: | Lei Zhang Xiao-Dong Sun |
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| Affiliation: | Lei Zhang,Xiao-Dong Sun Department of Ophthalmology,the First People's Hospital Affiliated Shanghai Jiaotong University,Shanghai 200080,China |
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| Abstract: | Epidermal growth factor(EGF)combining with ep-idermal growth factor receptor(EGFR)plays an important role in inducing cell proliferation,migration,adhesion and so forth by specific signal transduction.Recently,EGF/EGFR was found to stimulate retinal pigment ep-ithelial(RPE)cells to proliferate and migrate which induce the formation and development of proliferative vitreoretinopathy(PVR).We focused on the structure,function of EGF/EGFR as well as the mechanism of EGF/EGFR acting in PVR and also discussed the... |
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| Keywords: | EGF/EGFR PVR proliferation migration |
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