Efficacy and pharmacokinetics of fluvoxamine maleate in patients with mild depression undergoing hemodialysis |
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Authors: | Kamo Toshiko Horikawa Naoshi Tsuruta Yukio Miyasita Misako Hatakeyama Hiroshi Maebashi Yasuhiko |
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Affiliation: | Department of Psychiatry, Tokyo Women's Medical University and Tsuruta Clinic, Tokyo, Japan. tkano@psy.twmu.ac.jp |
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Abstract: | Seven Japanese patients on maintenance hemodialysis who were comorbid with mild depression were medicated with 50 mg/day fluvoxamine maleate for 28 days. Effectiveness was obtained in four out of seven patients (57%). The plasma fluvoxamine concentrations were examined in three patients. The plasma fuvoxamine concentration decreased by 22% by hemodialysis. There is a tendency for the dialyzed rate of fluvoxamine to become lower if the plasma albumin concentration is higher. The half-life of fluvoxamine was possibly shortened more in the patient with hypoalbuminaemia. The plasma fluvoxamine concentration reached a steady state 8 days after the start of medication and thereafter. The time required to reach steady state was lengthened when compared with the results in normal Japanese volunteers. |
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Keywords: | depression fluvoxamine maleate hemodialysis pharmacokinetics |
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