| 吐温-80对呋喃西林溶液稳定性的影响 |
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| 引用本文： | 常明泉,张幼林,袁胜浩,杨翠,陈芳. 吐温-80对呋喃西林溶液稳定性的影响[J]. 中国药事, 2010, 24(3): 293-294,309 |
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| 作者姓名： | 常明泉 张幼林 袁胜浩 杨翠 陈芳 |
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| 作者单位： | 1. 郧阳医学院附属太和医院,十堰,442000
2. 郧阳医学院 |
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| 摘 要： | 目的考察超声条件下不同浓度吐温-80对呋喃西林的增溶作用,筛选吐温-80的最佳用量,提高呋喃西林溶液的稳定性。方法用超声振荡仪将呋喃西林进一步粉碎成更细小的微粒,加入吐温-80做增溶剂配制呋喃西林溶液,样品置2-8℃的低温环境中冷贮3个月观察稳定性。结果加入0.5%吐温-80制备的呋喃西林溶液析出结晶少于对照品;加入1.0%与2%吐温-80制备的呋喃西林溶液无结晶析出,含量符合规定。结论吐温-80能增加呋喃西林的溶解度,用于呋喃西林溶液的制备能提高制剂稳定性。
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| 关 键 词： | 呋喃西林 吐温-80 增溶 稳定性 超声波 |
Influence on Stability of Nitrofurazone Solution with Tween-80 |
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| Chang Mingquan,Zhang Youlin,Yuan Shenghao,Yang Cui,Chen Fang. Influence on Stability of Nitrofurazone Solution with Tween-80[J]. Chinese Pharmaceutical Affairs, 2010, 24(3): 293-294,309 |
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| Authors: | Chang Mingquan Zhang Youlin Yuan Shenghao Yang Cui Chen Fang |
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| Affiliation: | Chang Mingquan,Zhang Youlin,Yuan Shenghao,Yang Cui1 , Chen Fang*(Affiliated Taihe Hospital of Yunyang Medical College,Shiyan 442000,1Pharmacy Department Yunyang Medical College) |
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| Abstract: | Objective To study the solubilization role of Tween-80 and ultrasonic inspection which may improve the stability of Nitrofurazone Solution,and optimize the content of Tween-80 in Nitrofurazone Solution.Methods Nitrofurazone was crushed into small particles by ultrasound at 50℃,and plus Tween-80 as solvents in Nitrofurazone Solution.The stability of Nitrofurazone Solution was studied by deposit at 2～8 ℃ for three months.Results The crystal of Nitrofurazone Solution with 0.5% Tween-80 was less than that of reference.There＇s no crystal in Nitrofurazone Solution with 1.0% and 2.0% Tween-80,and the content accords with the provisions.Conclusion Tween-80,which can improve the stability of Nitrofurazone Solution,can be used as solubilization of Nitrofurazone Solution. |
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| Keywords: | nitrofurazone Tween-80 solubilization stability ultrasonic |
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