首页 | 本学科首页   官方微博 | 高级检索  
     


Bronchopulmonary dysplasia – prevalence,severity and predictive factors in a national cohort of extremely premature infants
Authors:T Farstad,D Bratlid,S Medb  ,T Markestad
Affiliation:1. Department of Pediatrics, Akershus University Hospital, L?renskog, Norway;2. Department of Laboratory Medicine, Children’s and Women’s Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway;3. Department of Pediatrics, St. Olavs University Hospital, Trondheim, Norway;4. Department of Pediatrics Ullev?l, University Hospital, Oslo, Norway;5. Department of Clinical Medicine, University of Bergen, Bergen, Norway;6. Department of Pediatrics Haukeland University Hospital, Bergen, Norway
Abstract:Aim: To study prevalence and predictive factors of bronchopulmonary dysplasia (BPD) in a cohort of preterm infants with a high incidence of prenatal steroid and surfactant treatment. Methods: BPD was analysed in a national cohort of infants with gestational age (GA) of 22–27 completed weeks (wks) or birth weight (BW) of 500–999 g. Of 464 infants who were transferred to a NICU, 377 infants with GA ≤ 30 wks and survived beyond 28 days were included in the study. Results: Moderate or severe BPD was strongly related to GA. Of infants with GA 22–25 wks, 67.3% developed BPD compared to 36.6% at GA 26–30 wks. Overall, moderate and severe BPD was significantly more common in boys (63.3%) than in girls (36.6%) (p = 0.0004), but female gender was not a protective factor in infants with GA 22–25 wks. In multivariate analyses, BPD was significantly associated with gender, surfactant treatment and treatment for PDA. Conclusions: BPD remains a severe complication of extreme prematurity in spite of prenatal steroids and surfactant treatment. Whether associations with surfactant and PDA treatment simply reflect severity of early lung disease or have causal relationships should probably be studied in randomized controlled trials.
Keywords:Bronchopulmonary dysplasia  Extremely low birth weight infants  Patent ductus arteriosus  Prenatal steroids  Surfactant
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号