Kidney Transplant from the Same Donor without Maintenance Immunosuppression after Previous Hematopoietic Stem Cell Transplant |
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| Authors: | J Fangmann H Kathrin Al‐Ali U Sack M Kamprad H M Tautenhahn S Faber J Hauss D Niederwieser T Lindner A Bachmann |
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| Institution: | 1. Department of Surgery, Karl Olga Hospital Stuttgart, Stuttgart, Germany;2. Department of Internal Medicine, Neurology and Dermatology, Division of Hematology and Oncology, University Hospital Leipzig, Leipzig, Germany;3. Translational Centre for Regenerative Medicine (TRM), University of Leipzig, Leipzig, Germany;4. Institute of Clinical Immunology, University Hospital Leipzig, Leipzig, Germany;5. Department of Surgery, University Hospital Leipzig, Leipzig, Germany;6. Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany;7. Department of Internal Medicine, Neurology and Dermatology, Division of Nephrology, University Hospital Leipzig, Leipzig, Germany |
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| Abstract: | In January 2005, an 18‐year‐old male patient with acute myeloid leukemia (AML) received a haploidentical hematopoietic stem cell transplantation (HSCT) from his father. He developed hemolytic uremic syndrome and end‐stage renal disease (ESRD) requiring hemodialysis on day 357 after HSCT. On day 1020 after HSCT, a living kidney donation from the stem cell donor was carried out. The creatinine before kidney transplantation (KT) was ≈450 μmol/L, 268 μmol/L on day 2 after KT, 88 μM on day 38 and 89 μmol/L on day 960 (day 1980 after HSCT). Immunosuppression was gradually discontinued: cortisone on day 28, tacrolimus on day 32 and MMF on day 100 after KT (day 1120 after HSCT). As of June 2010, 66 months after HSCT and 32 months after KT, the patient has had neither rejection episodes nor clinical manifestations of transplantation‐related complications. The patient reached 100% hematopoietic donor chimerism prekidney transplant and retained this state postkidney transplant. This unique case is the first report of a successful kidney transplant without immunosuppression after HSCT from the same haploidentical donor. |
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| Keywords: | Immunosuppression kidney allograft kidney transplantation leukemia renal transplant tolerance transplant immunology |
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