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Evidence for a possible anatomical subsite–mediated effect of tobacco in oral potentially malignant disorders and carcinoma |
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| Authors: | Monica Pentenero Walter Giaretti Roberto Navone Isabella Rostan Lavinia Gassino Roberto Broccoletti Paolo Giacomo Arduino Davide Malacarne Sergio Gandolfo |
| Institution: | 1. Department of Clinical and Biological Sciences, Oral Medicine and Oral Oncology Section, University of Turin, Italy;2. Department of Advanced Diagnostic Technologies, Biophysics and Cytometry Section, National Cancer Research Institute, Genoa, Italy;3. Department of Biomedical Sciences and Human Oncology, Pathology Section, University of Turin, Italy;4. Department of Biomedical Sciences and Human Oncology, Oral Medicine Section, University of Turin, Italy |
| Abstract: | J Oral Pathol Med (2011) 40 : 214–217 Purpose: To test the hypothesis that cigarette smokers develop oral potentially malignant disorders or carcinomas in preferential anatomical subsites. Methods: The association of smoking habit with the presence of oral lesions in specific anatomical subsites was assessed in 123 patients using the odds ratio analysis. Results: When compared to all the other subsites, the relative frequency of smokers with lesions was higher in the buccal mucosa and in the floor of the mouth (FOM) (P = 0.002 and P = 0.005), while it was lower in the tongue (P < 0.0005). Smokers were about 7 years younger than non‐smokers (P = 0.008). Conclusions: The association of smoking and age suggests that smoking may contribute to generate a field of injury that leads to lesions in shorter periods than other causes. The stronger relationship of smoking with lesions in the buccal mucosa and FOM than in the tongue suggests that tissue characteristics mediate the effects of tobacco. |
| Keywords: | oral anatomical subsite oral potentially malignant disorders oral squamous cell carcinoma patient age tobacco cigarette smoking |