Current controversies on the role of lymphadenectomy for prostate cancer |
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| Authors: | Charbel Chalouhy Sandeep Gurram Reza Ghavamian |
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| Affiliation: | 1. St. Joseph University, Faculty of Medicine, Beirut, Lebanon;2. The Smith Institute for Urology, Zucker School of Medicine Hofstra/Northwell, New Hyde Park, NY |
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| Abstract: | Lymph node dissection is part of the standard treatment protocol for various cancers, but its role in prostate cancer has been debatable for some time. Pelvic lymphadenectomy has been shown to better help stage prostate cancer patients, but has yet to be definitively proven to be of any benefit for survival. Various templates for lymph node dissections exist, and though some national guidelines have endorsed an extended pelvic node dissection, the choice of template is still controversial. Pelvic lymphadenectomy may lead to a slightly higher rate complications and operative time, and their use must be judiciously applied to patients with a high enough risk of lymph node involvement. We present a comprehensive review of the literature regarding the benefits and harms of lymph node dissection in prostate cancer. |
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| Keywords: | Prostate cancer Lymph node Lymphadenectomy NCCN National Comprehensive Cancer Network ePLND extended pelvic node dissection lPLND limited pelvic node dissection PLND pelvic lymphadenectomy VTE venous thromboembolism PSA prostate-specific antigen LNI lymph node invasion AUC area under the curve BCR biochemical recurrence ADT androgen deprivation therapy HR hazard ratio 68 Gallium-68-prostate-specific membrane antigen |
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