首页 | 本学科首页   官方微博 | 高级检索  
检索        


Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation,Stemness, and BrafV600E-Induced Tumorigenesis
Authors:Yong Tao  Byunghak Kang  Daniel A Petkovich  Yuba R Bhandari  Julie In  Genevieve Stein-O&#x;Brien  Xiangqian Kong  Wenbing Xie  Nicholas Zachos  Shinji Maegawa  Himani Vaidya  Stephen Brown  Ray-Whay Chiu Yen  Xiaojian Shao  Jai Thakor  Zhihao Lu  Yi Cai  Yuezheng Zhang  Hariharan Easwaran
Institution:1. CRB1, Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Room 530, Baltimore, MD 21287, USA;2. Hopkins Conte Digestive Disease, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;3. Division of Biostatistics & Bioinformatics, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA;4. Department of Pediatrics, University of Texas, MD Anderson Cancer Center, Unit 853, 1515 Holcombe Boulevard, Houston, TX 77030, USA;5. Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19122, USA;6. Department of Human Genetics, Canadian Centre for Computational Genomics, McGill University, Montreal, QC, Canada;7. Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing 100142, China;8. Department of Pathology, University of Washington, Seattle, WA 98195, USA;9. Germans Trias i Pujol Health Science Research Institute (IGTP), Program for Personalized Medicine of Cancer, Badalona, 08916 Catalonia, Spain
Abstract:
/><ol class=
  • Download high-res image (116KB)
  • Download full-size image
  • Keywords:tumorigenesis  CpG-island DNA methylation  epigenetic silencing  transformation  aging  tumor predisposition  cancer risk  CIMP  colon adenocarcinomas
    本文献已被 ScienceDirect 等数据库收录!
    设为首页 | 免责声明 | 关于勤云 | 加入收藏

    Copyright©北京勤云科技发展有限公司  京ICP备09084417号