| 人参皂甙的抗肿瘤作用及其机制 |
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| 引用本文： | 杨玉琪,李玛琳. 人参皂甙的抗肿瘤作用及其机制[J]. 药学进展, 2003, 27(5): 287-290 |
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| 作者姓名： | 杨玉琪 李玛琳 |
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| 作者单位： | 1. 云南省中医中药研究所,云南,昆明,650223
2. 昆明医学院云南天然药物药理重点实验室,云南,昆明,650031 |
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| 摘 要： | 人参皂甙的抗肿瘤作用机制较为广泛，主要表现为直接作用于癌细胞，通过诱导细胞凋亡抑制肿瘤生长或诱导细胞分化使其逆转；作用于肿瘤侵袭的多个环节抑制其转移；逆转肿瘤的耐药性提高化疗药物的抗肿瘤活性；调节免疫功能增强机体抗肿瘤能力；影响细胞连接通讯或抑制酶的活性及拮抗致癌剂的作用等。
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| 关 键 词： | 人参皂甙 抗肿瘤作用 癌细胞 细胞凋亡 |
| 文章编号： | 1001-5094(2003)05-0287-04 |
| 修稿时间： | 2003-04-14 |
Antitumor Activities and Mechanisms of Ginsenosides |
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| Yang Yu-qi ,Li Ma-lin. Antitumor Activities and Mechanisms of Ginsenosides[J]. Progress in Pharmaceutical Sciences, 2003, 27(5): 287-290 |
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| Authors: | Yang Yu-qi Li Ma-lin |
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| Affiliation: | Yang Yu-qi 1,Li Ma-lin 2 |
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| Abstract: | Ginsenosides have activities in the prevention and treatment of cancer. Ginsenosides can inhibit the proliferation of cancer cell by inducing apoptosis and reversing differentiation state, block the metastasis of cancer by infecting different process of invasion, increase chemotherapy efficiency by reversing drug-resistance, and enhance resistance from cancer via their immunomodulatory activity, preventing from cancer induced by carcinogen by affecting intercellular communication and inhibiting the activity of certain enzymes. |
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| Keywords: | Ginsenosides Anticacer Mechanism |
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