2型糖尿病视网膜病变严重程度与血清生化全套指标的相关性

目的:分析不同程度2型糖尿病视网膜病变的血清生化全套指标,探讨各生化指标与糖尿病性视网膜病变(diabetic retinopathy,DR)程度的相关性.方法:回顾性收集2018年5月至2020年10月在福建医科大学附属第二医院就诊的2型糖尿病患者.根据眼底情况分为3组:糖尿病不伴视网膜病变(non-diabetic...

Correlation between the severity of type 2 diabetic retinopathy and the serum biochemical indexes

Objective:To analyze the serum biochemical indexes of different degrees of type 2 diabetic retinopathy,and the correlation between biochemical indexes and the degree of diabetic retinopathy(DR).Methods:Patients with type 2 diabetes admitted to the Fujian Medical University 2nd Affiliate Hospital from May 2018 to October 2020 were retrospectively collected.The patients were divided into 3 groups according to fundus conditions:non-diabetic retinopathy(NDR)group(n=17),diabetes with non-proliferative diabetic retinopathy(NPDR)group(n=29),diabetes with proliferative diabetic retinopathy(PDR)group(n=34).SPSS 24.0 was used to compare the levels of a complete set of serum biochemical indexes in the three groups.Pearson correlation analysis and multiple linear regression analysis were used for the correlation between the different indexes and DR.Results:There was no statistically significant difference in age between the three groups.The differences in total protein,albumin,white sphere ratio,and calcium concentration of the three groups were statistically significant(P<0.05).The comparison between the groups showed that the total protein,albumin,white sphere ratio,and calcium concentration in the NPDR and PDR groups were lower than those in the NDR group.The difference was statistically significant(P<0.05).Pearson correlation analysis showed that total protein(r=?0.290),albumin(r=?0.304),and calcium concentration(r=?0.252)were negatively correlated with DR(all P<0.05).Multiple linear regression indicated total protein,albumin and blood calcium concentration were the protective factors of DR(P<0.05).Conclusion:This study found that serum levels of total protein,albumin,and blood calcium levels are negatively correlated with DR.Maintaining a relatively high level of these indexes within the physiological range may provide new ideas for the prevention and treatment of diabetic retinopathy.