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急慢性胰腺炎后新发2型糖尿病的危险因素Meta分析
引用本文:梁艺钟,张维晴,郭绍举,姜小艳,张春虹,刘禹翔.急慢性胰腺炎后新发2型糖尿病的危险因素Meta分析[J].中国临床研究,2021(3):314-318.
作者姓名:梁艺钟  张维晴  郭绍举  姜小艳  张春虹  刘禹翔
作者单位:深圳市中医院脾胃科;深圳市龙华区人民医院中医科;深圳市中医院急诊科
基金项目:国家自然科学青年基金(81703869)。
摘    要:目的系统评价急慢性胰腺炎患者新发2型糖尿病危险因素的相关研究。方法计算机检索中英文数据库,筛选符合纳入标准的病例对照研究,病例组为急慢性胰腺炎患者中新发2型糖尿病的患者,对照组为急慢性胰腺炎患者中未并发2型糖尿病的患者,对纳入的研究进行质量评估,提取数据并采用Review Manager5.3进行Meta分析及系统评价。结果最终7篇文献符合纳入标准,含高质量文献4篇,纳入患者4618例,Meta分析结果显示:男性、有饮酒史、首发住院年龄较大、首发年龄较大、有吸烟史、吸烟量较多、乙醇摄入量较多、重症胰腺炎、酒精性胰腺炎为急慢性胰腺炎患者新发2型糖尿病的危险因素(P<0.05,P<0.01)。结论针对主要危险因素采取相应预防措施,加强急慢性胰腺炎的随访管理,有利于降低胰腺炎患者新发2型糖尿病的发病率。

关 键 词:胰腺炎  2型糖尿病  危险因素  荟萃分析  系统评价

Risk factors for new onset type 2 diabetes after acute and chronic pancreatitis:a Meta-analysis
LIANG Yi-zhong,ZHANG Wei-qing,GUO Shao-ju,JIANG Xiao-yan,ZHANG Chun-hong,LIU Yu-xiang.Risk factors for new onset type 2 diabetes after acute and chronic pancreatitis:a Meta-analysis[J].Chinese Journal of Clinical Research,2021(3):314-318.
Authors:LIANG Yi-zhong  ZHANG Wei-qing  GUO Shao-ju  JIANG Xiao-yan  ZHANG Chun-hong  LIU Yu-xiang
Institution:(Department of Spleen and Stomach,Shenzhen Traditional Chinese Medicine Hospital,Shenzhen,Guangdong 518033,China)
Abstract:Objective To systematically evaluate the relevant studies on risk factors for new onset type 2 diabetes in patients with acute and chronic pancreatitis.Methods A computerized search of Chinese and English databases was performed to screen case-control studies that met the inclusion criteria:the subjects in the case group were patients with new onset type 2 diabetes among acute and chronic pancreatitis,the subjects in the control group were patients with uncomplicated type 2 diabetes among acute and chronic pancreatitis,the included studies were qualitatively assessed,the data were extracted and meta-analysis and systematic review were performed using Review Manager5.3.Results The final 7 articles met the inclusion criteria,including 4 high-quality articles with 4618 included patients,and the results of the meta-analysis showed that being male,having a history of alcohol consumption,older age at first hospitalization,older age at first episode,having a history of smoking,more tobacco use,more ethanol intake,severe pancreatitis,and alcoholic pancreatitis were risk factors for new onset type 2 diabetes in patients with acute and chronic pancreatitis.Conclusion Targeting the major risk factors with corresponding preventive measures to enhance the follow-up management of acute and chronic pancreatitis is beneficial to reduce the incidence of new onset type 2 diabetes in patients with pancreatitis.
Keywords:Pancreatitis  Type 2 diabetes  Risk factors  Meta analysis  Systematic review
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