抗LGi1抗体相关脑炎血清LGil抗体转阴1例及文献复习

目的 探讨富亮氨酸胶质瘤失活1蛋白(leucine-rich glioma inactivated-1,LGi1)抗体相关脑炎(简称抗LGi1抗体相关脑炎)临床特点、血清抗体转阴的时间及特点.方法 回顾性分析1例血清富亮氨酸胶质瘤失活1蛋白抗体转阴的LGi1脑炎临床资料.观察患者临床表现、实验室检查、影像学检查及治疗转...

Leucine-rich glioma-inactivated 1 protein antibody-associated encephalitis with protein antibody turning negative:a case report and literature review

Objective To explore the clinical characteristics of leucine-rich glioma inactivation 1 protein(LGi1)antibody-associated encephalitis and the time of serum antibody turning negative.Methods A 52-year-old female patient presented with paroxysmal involuntary movement in left upper limb and face for 2.5 months and intermittent convulsions,unconsciousness and fever for 1 week.Nervous system examination found neck rigidity and positive bilateral kerning sign.Serum anti-LGi1 antibody was positive(1∶100).After being diagnosed as anti-LGi1 antibody related encephalitis,the patient was given a comprehensive treatment including hormone,gamma globulin and levetiracetam.She was hospitalized for 14 days and followed up for 12 months.Results One month after discharge,the patient was completely relieved of her clinical symptoms,but with still positive serum LGi1 antibody(1∶100).At 3,6 and 12 months after discharge,the clinical symptoms did not recur,and all serum LGi1 antibodies were negative.Conclusion In the patient with LGi1 antibody encephalitis,positive serum LGi1 antibody can turn negative.The time of clinical symptoms alleviating is not synchronized with the time of negative antibody transformation.