脑微出血患者血清基质金属蛋白酶-9与出血部位及严重程度的相关性

目的:探讨血清基质金属蛋白酶-9(matrix metalloproteinases-9，MMP-9)水平与脑微出血(cerebral microbleeds，CMBs)部位及严重程度的相关性。方法:2019年1月至2020年8月经新乡医学院第一附属医院神经内科收治并予以头颅MRI检测有CMBs患者60例作为CMBs组...

Correlation between serum matrix metalloproteinase-9 level and location and severity of bleeding in patients with cerebral microbleeds

Objective To investigate the relationship between serum matrix metalloproteinase-9(MMP-9)level and the location and severity of bleeding in patients with cerebral microbleeds(CMBs).Methods A total of 60 CMBs patients admitted to the Department of Neurology of the First Affiliated Hospital of the Xinxiang Medical University from January 2019 to August 2020 were selected as subjects as the CMBs group,and 60 healthy controls without nervous system diseases in outpatient physical examination during the same period were selected as the control group.The clinical data and biochemical indicators of the two groups were collected.Serum MMP-9 levels were measured by enzyme linked immunosorbent assay(ELISA).According to susceptibility weighted imaging(SWI),CMBs patients were divided into grade 1 group(n=24),grade 2 group(n=19)and grade 3 group(n=17),and according to the micro analytical rating scale(MARS),the CMBs patients were divided into the lobar group(n=19),the deep or infratentorial group(n=17)and the mixed group(n=24).The relationship between serum MMP-9 level and the location and severity of CMBs was analyzed.SPSS 19.0 software was used for data statistical analysis.One-way ANOVA,t-test and rank sum test were used for comparison.Logistic regression analysis was used to analyze the influencing factors.Pearson correlation analysis and Spearman correlation analysis were used for correlation analysis.Results The level of MMP-9 in CMBs group was significantly higher than that in control group(208.13(142.25,285.88)μg/L,149.50(93.40,186.51)μg/L),and the difference was statistically significant(P<0.05).Serum MMP-9 level was a risk factor of CMBs(β=1.322,OR=3.750,95%CI=2.038-7.997,P=0.002).The difference of level of MMP-9 in different severity of CMBs was statistically significant(147.55(109.25,266.47)μg/L,242.12(147.55,288.80)μg/L,270.42(203.43,364.27)μg/L,P=0.017).Serum MMP-9 level was positively correlated with the number of CMBs(r=0.371,P=0.003).The difference of MMP-9 level of CMBs in different locations were statistically significant(249.77(158.43,338.46)μg/L,188.83(138.52,243.15)μg/L,210.65(144.25,255.78)μg/L,P=0.013).The increased serum MMP-9 level was a risk factor for CMBs(β=0.401,OR=1.122,95%CI=1.004-1.204,P=0.036).Conclusion The increased level of serum MMP-9 may be a risk factor of CMBs,especially for CMBs in cerebral lobesand,and the level of MMP-9 is positively correlated with the severity of CMBs.