增强型体外反搏联合曲美他嗪治疗冠心病慢性心力衰竭患者的效果

目的:观察增强型体外反搏联合曲美他嗪治疗冠心病慢性心力衰竭患者的效果。方法:回顾性分析2018年3月至2019年8月该院收治的74例冠心病慢性心力衰竭患者的临床资料,依据治疗方法不同将其分为观察组和对照组各37例。两组均进行常规治疗,在此基础上,对照组采用曲美他嗪治疗,观察组采用增强型体外反搏联合曲美他嗪治疗。比较两组疗效,治疗前后心功能指标水平、血清炎性因子水平和6 min步行试验(6MWT)距离。结果:观察组治疗总有效率为97.30%(36/37),高于对照组的78.38%(29/37),差异有统计学意义(P<0.05);治疗后,观察组左室射血分数(LVEF)高于对照组,差异有统计学意义(P<0.05);治疗后,两组左室舒张末期内径和左室收缩末期内径比较,差异均无统计学意义(P>0.05);治疗后,观察组肿瘤坏死因子-α、超敏C反应蛋白和白细胞介素-6水平均低于对照组,6MWT距离长于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:增强型体外反搏联合曲美他嗪治疗冠心病慢性心力衰竭的效果显著,可提高LVEF水平,降低血清炎性因子水平,延长6MWT距离,且安全性良好。

Effects of enhanced external counterpulsation combined with Trimetazidine in treatment of patients with coronary heart disease and chronic heart failure

Objective:To explore effects of enhanced external counterpulsation combined with Trimetazidine in treatment of patients with coronary heart disease and chronic heart failure.Methods:The clinical data of 74 patients with coronary heart disease and chronic heart failure admitted to the hospital from March 2018 to August 2019 were retrospectively analyzed.According to different treatment methods,they were divided into observation group and control group,each with 37 cases.Both groups received conventional treatment.On this basis,the control group was treated with Trimetazidine,while the observation group was treated with enhanced external counterpulsation combined with Trimetazidine.The curative effects and the levels of heart function indexes,serum inflammatory factors and 6-minute walking test(6MWT)distance before and after the treatment were compared between the two groups.Results:The total effective rate of treatment in the observation group was 97.30%(36/37),which was higher than 78.38%(29/37)in the control group,and the difference was statistically significant(P<0.05).After the treatment,the left ventricular ejection fraction(LVEF)of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After the treatment,there were no significant differences between the two groups in the left ventricular end diastolic diameter and left ventricular end systolic diameter(P>0.05).Further,after the treatment,the levels of tumor necrosis factor-α,high-sensitivity C-reactive protein and interleukin 6 in the observation group were lower than those in the control group;the 6MWT distance was longer than that in the control group;and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Enhanced external counterpulsation combined with Trimetazidine has a significant effect in the treatment of coronary heart disease and chronic heart failure.It can increase the LVEF level,reduce the serum inflammatory factor levels,and extend the distance of 6MWT with good safety.