| 腺苷酸活化蛋白激酶途径与肿瘤的研究进展 |
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| 引用本文： | 牛海英. 腺苷酸活化蛋白激酶途径与肿瘤的研究进展[J]. 医学综述, 2015, 21(1): 52-55 |
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| 作者姓名： | 牛海英 |
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| 作者单位： | 包头医学院临床医学系,内蒙古包头,014010 |
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| 摘 要： | 腺苷酸活化蛋白激酶(AMPK)是哺乳动物细胞中高度保守的蛋白质,是细胞的重要的代谢感受器。哺乳动物雷帕霉素靶蛋白(m TOR)信号通路,是一种不典型的丝/苏氨酸激酶,在进化中也具有高度保守性,主要通过调控蛋白合成来调节细胞的生长,m TOR激酶通过多种信号通路来实现对细胞生长的调节作用,其中营养信号激活通路为细胞外的氨基酸通路LKB1-AMPK途径。二甲双胍(LKB1/AMPK的激活剂),可抑制m TOR的活性,从而可以应用于多种肿瘤的治疗,目前研究表明AMPK信号通路及其相关的信号通路与多种肿瘤的发生、发展有关。
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| 关 键 词： | 腺苷酸活化蛋白激酶 肝激酶B1 雷帕霉素靶蛋白信号途径 二甲双胍 肿瘤 |
Advance in Research on the Relationship between Adenosine Monophosphate Activated Protein Kinase Signaling Pathway and Tumor |
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| NIU Hai-ying. Advance in Research on the Relationship between Adenosine Monophosphate Activated Protein Kinase Signaling Pathway and Tumor[J]. Medical Recapitulate, 2015, 21(1): 52-55 |
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| Authors: | NIU Hai-ying |
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| Affiliation: | NIU Hai-ying;WANG Zhan-li;Department of Clinical Medicine,Baotou Medical University;Department of Clinical Laboratory,the First Affiliated Hospital of Baotou Medical University; |
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| Abstract: | |
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| Keywords: | Adenosine monophosphate activated protein kinase Liver kinase B1 Signaling pathway of target of rapamycin Metformin Tumor |
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