血清内脂素、脂联素和C-反应蛋白与冠状动脉病变的相关性

目的探讨血清内脂素(Visfantin)、脂联素(APN)和C-反应蛋白(CRP)与冠状动脉病变的关系。方法70例经冠状动脉造影确诊的冠状动脉粥样硬化性心脏病(冠心病)患者作为观察组,并根据血管病变情况分为单支病变组、双支病变组、多支病变组,另选20例健康体检者作为对照组,采用酶联免疫吸附试验测定血清Visfantin、APN、CRP水平,比较不同程度病变者血清Visfantin、APN、CRP的差异及其与冠状动脉病变的相关性。结果观察组血清Visfantin、CRP水平均显著高于对照组(P<0.01),APN水平显著于低于对照组(P<0.01)。双支病变组和多支病变组血清CRP、Visfantin水平及Gensini积分均明显高于单支病变组(P<0.05);多支病变组血清Visfantin、CRP水平及Gensini积分显著高于双支病变组(P<0.05)。双支病变组和多支病变组的APN水平均低于单支病变组(P<0.05),但双支病变组和多支病变组比较差异无统计学意义(P>0.05)。血清Visfantin与CRP(r=0.929,P<0.001)、Gensini积分(r=0.777,P<0.001)呈正相关,与APN(r=-0.351,P<0.001)呈负相关;APN与CRP(r=-0.873,P<0.001)、Gensini积分(r=-0.740,P<0.001)呈负相关;CRP与Gensini积分呈正相关(r=0.692,P<0.001)。结论血清Visfantin、APN、CRP均可能是冠心病的危险因素,对评估冠状动脉病变程度有重要价值。

Relationships of serum visfatin,adiponectin and C-reactive protein with coronary artery disease

Objective To discuss the relationships of serum visfatin,adiponectin(APN) and C-reactive protein(CRP) with coronary artery disease.Methods Seventy patients with coronary heart disease who were confirmed by coronary angiography were selected as observation group,and according to the number of vascular lesion,the patients were divided into three subgroup:single-vessel disease group,double-vessel disease group and muti-vessel disease group.In addition,20 healthy people were selected as control group.Serum visfatin,APN and CRP levels were measured by enzyme-linked immunosorbent assay.The differences of them in different severity of coronary artery disease patients and the the relationships of serum visfatin,APN and CRP with coronary artery disease were analyzed.Results Compared with the control group,serum visfatin and CRP levels were significantly increased(P<0.01),APN level was significantly decreased in observation group(P<0.01).Serum visfatin,CRP levels and Gensini points in double or multi-vessel disease group were significantly higher than in single-vessel disease group(P<0.05);and the indexes in multi-vessel disease group were significantly higher than in double-vessel disease group(P<0.05).Serum APN level in double or multi-vessel disease group was higher than single-vessel disease group(P<0.05).However,there was no significant difference in serum APN between double-vessel disease group and multi-vessel disease group(P>0.05).Multiple correlation analysis showed that serum visfatin level was positively correlated with the serum level of CRP(r=0.929,P<0.001)and Genisini points(r=0.777,P<0.001),negatively correlated with the serum level of APN(r=-0.351,P<0.001).Serum APN level was negatively correlated with the serum level of CRP(r=-0.873,P<0.001)and Genisini points(r=-0.740,P<0.001).Serum CRP level was positively correlated with Genisini points(r=0.692,P<0.001).Conclusion Visfatin,APN and CRP levels may be risk factors for coronary heart disease.They all have significant value to evaluate degree of coronary artery disease.