| 原发性鼻粘膜恶性黑色素瘤病理和免疫组化观察 |
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| 引用本文： | 徐纪为,陈丽荣,王培基,李智渊. 原发性鼻粘膜恶性黑色素瘤病理和免疫组化观察[J]. 中华耳鼻咽喉头颈外科杂志, 1995, 0(2) |
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| 作者姓名： | 徐纪为 陈丽荣 王培基 李智渊 |
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| 作者单位： | 温州医学院第一医院病理科，浙江医科大学肿瘤研究所，温州医学院第一医院耳鼻咽喉科 |
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| 摘 要： | 报道４０例原发性鼻粘膜恶性黑色素瘤（手术和活检标本各２０例）的病理和免疫组化观察，结果显示本瘤大体上１４例呈息肉状。光镜形态以多种细胞类型和组织形态混合存在为主要特点．免疫组化染色显示本瘤Ｓ－１００蛋白和波纹蛋白阳性率分别为９０％和７７．５％，角蛋白阴性。认为本瘤的组织发生可能来自鼻腔粘膜先前存在的黑色素细胞。组织学的多形性和免疫组化Ｓ－１００蛋白及波纹蛋白阳性对诊断本瘤的无色素型有重要意义。
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| 关 键 词： | 鼻粘膜，黑素瘤，免疫化学 |
Pathological and Imnunohistochemical Studies on Primary Nasal Mucosal Malignant Melanoma |
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| Xu Jiwei,Chen Lirong,Wang Peiji ,et al.. Pathological and Imnunohistochemical Studies on Primary Nasal Mucosal Malignant Melanoma[J]. Chinese journal of otorhinolaryngology head and neck surgery, 1995, 0(2) |
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| Authors: | Xu Jiwei Chen Lirong Wang Peiji et al. |
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| Abstract: | The pathological and immunohistochemical features of primary nasal mucosal malignant melanoma(PNMMM)were reuorted in 40 cases.The results showed that approximate 70%of PNM-MM was polypoid.The principal features were the mixed existance of different cellular patterns and morphologies.Immunohistochemically ,PNMMM reactitvity to S-100 protein and vimentin was 90% and 77.5%,respectively,along with no reactivity to Keratin .We believe that PNMMM may arise from preexistant melocytes in nasal mucosa .Histological Pleomorphism and immunohistochemical reactivity to S-100 protein and vimentinwere of importance for diagnosis of PMMM ,especially for the amelanotic type. |
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| Keywords: | Nasal mucosa Melanoma Immunochemistry |
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