| 左旋肉碱改善顺铂诱导肾损伤机制的相关研究 |
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| 引用本文： | 李敏,那宇,高建军. 左旋肉碱改善顺铂诱导肾损伤机制的相关研究[J]. 安徽医药, 2015, 0(1): 10-13. DOI: 10.3969/j.issn.1009-6469.2015.01.003 |
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| 作者姓名： | 李敏 那宇 高建军 |
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| 作者单位： | 1. 安徽医科大学解放军 306 临床学院;2. 中国人民解放军 306 医院肾内科,北京,100101 |
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| 基金项目： | 全军医学科技青年培育项目(NO 13QNP088) |
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| 摘 要： | 左旋肉碱可有效改善某些药物引起的肾损伤，其在顺铂诱导的急性肾损伤中起保护作用。多数研究认为左旋肉碱主要通过抗氧化、抗炎及抗凋亡作用发挥对顺铂肾毒性的保护作用，但目前发现其机制还涉及其他方面。该文就左旋肉碱改善顺铂肾损伤的相关研究综述如下。
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| 关 键 词： | 左旋肉碱 顺铂 肾损伤 机制 |
Correlation studies of the mechanisms of L-carnitine improving the renal injury induced by cisplatin |
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| LI Min;NA Yu;GAO Jian-jun. Correlation studies of the mechanisms of L-carnitine improving the renal injury induced by cisplatin[J]. Anhui Medical and Pharmaceutical Journal, 2015, 0(1): 10-13. DOI: 10.3969/j.issn.1009-6469.2015.01.003 |
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| Authors: | LI Min NA Yu GAO Jian-jun |
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| Affiliation: | LI Min;NA Yu;GAO Jian-jun;The 306th Clinical Hospital of the People’s Liberation Army,Anhui Medical University;Department of Nephrology,The 306th Hospital of the People’s Liberation Army; |
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| Abstract: | L-carnitine can effectively inhibit the drug-induced renal injury.There is increased evidence that it can improve the renal in-jury induced by cisplatin.The properties of L-carnitine,such as anti-oxidant,anti-inflammatory and anti-apoptotic,are considered the main protection mechanisms of cisplatin renal toxicity.But now we find that the mechanisms are also involved in other aspects.In this paper,correlation studies of the mechanisms of L-carnitine improving the renal injury induced by cisplatin will be summarized. |
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| Keywords: | L-carnitine cisplatin renal injury mechanisms |
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