食管癌患者实施放化疗前后血管内皮生长因子改变与病理反应对预后疗效的影响分析

目的：研究食管癌患者实施放化疗前后血管内皮生长因子（VEGF）改变与病理反应对预后疗效的影响。方法收集该院肿瘤科2009年6月到2013年6月住院的食管鳞癌患者80例，按照随机数字表法分为试验组和对照组，每组40例，试验组给予放化疗，对照组给予单纯的放疗，采用酶链免疫吸附法，测定两组患者治疗前后 VEGF 水平，观察两组的指标并且分析与预后的关系。结果试验组治疗前 VEGF 水平为（569．22±255．25）ng·L －1，对照组治疗前 VEGF 水平为（610．51±275．18）ng·L －1，治疗前两组之间差异无统计学意义（P ＞0．05），试验组和对照组治疗后 VEGF 水平分别为（167．89±155．26）ng·L －1和（437．23±128．55）ng·L －1，治疗后两组之间的差别具有统计学意义（P ＜0．05），组内的比较试验组和对照组治疗前后 VEGF 水平的差异均具有统计学意义（P ＜0．05）；试验组的1、2、3年的生存率分别为81．2％、61．25％、49．12％，对照组的1、2、3年的生存率分别为55．34％、35．24％、21．23％，试验组的中位生存时间为32．19个月，对照组中位生存时间为20．56个月。两组生存率之间的差别具有统计学意义（P ＜0．05）。结论食管癌患者实施放化疗后 VEGF 的水平能显著降低，并且同期的放化疗与单纯的放疗比较可以明显的提高生存率。

mpact analysis of VEGF change and pathological reaction on prognosis of patients withesophageal cancer before and after radiation and chemotherapy

Objective To study the effect of change of VEGF and pathological response on prognosis of patients with esophageal cancer before and after the radiation and chemotherapy.Methods We collected 80 patients with esophageal squamous cell carcinomas from June 2009 to June 2013 in hospital,according to random number table method was divided into the experimental group and the control group,and 40 cases in each group,the treatment group was given radiation and chemotherapy,the control group was given simple radio-therapy,to use polymerase chain immune adsorption method,to measure the two groups before and after treatment in patients with VEGF levels,to observe two groups of indicators and analyse the relationship with the prognosis.Results The experimental group before the treatment level of VEGF was (569.22 ±255.25)ng·L -1 ,the control group before treatment of VEGF levels was (610.51 ±275.18) ng·L -1 ,it was no statistically significant difference between two groups before treatment (P >0.05),the treatment group and the con-trol group in VEGF levels after treatment respectively were (167.89 ±155.26)ng·L -1 and (437.23 ±128.55)ng·L -1 ,it had sta-tistically significant difference between two groups after treatment (P <0.05),the comparison of groups within the treatment group and the control group before and after treatment,the differences of the levels of VEGF had statistically significant (P <0.05);Group 1,2, 3 year survival rates were 81.2%,61.25%,49.12%,control group 1,2,3 year survival rate for 55.34%,35.24% and 21.23%,re-spectively,the test median survival time was 32.19 months,the control group median survival time was 20.56 months.The difference between two groups of survival had statistical significance (P <0.05).Conclusion Patients with esophageal cancer of the level of VEGF can significantly reduce after the implementation of radiation and chemotherapy,and at the same time of radiation and chemother-apy compared with pure radiotherapy can obviously improve the survival rate.