我院1056例药品不良反应报告分析

目的:了解我院药品不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:以我院2012年1-12月上报国家ADR监测中心的1 056例ADR报告为对象,对其一般情况、给药途径、药品种类、ADR累及器官或系统及临床表现等进行统计分析。结果:1 056例ADR报告中,年龄≥60岁的患者发生ADR比例最高(355例,占33.62%);静脉给药引起的ADR最多(986例,占93.37%);引起ADR最多的药物为抗菌药物(434例,占41.10%),其次为中药注射剂(288例,占27.27%);ADR损害类型主要以皮肤及其附件损害为主(460例,占43.56%)。结论:临床应加强ADR的监测与上报工作,促进临床合理用药。

Analysis of 1 056 ADR Reports in Our Hospital

OBJECTIVE： To analyze the characteristics and regularity of ADR reports in our hospital, and to provide reference for clinical drug use. METHODS： 1 056 ADR cases reported by our hospital to ADR monitoring center during Jan.--Dec. 2012 were analyzed in respects of gender information of patients, route of administration, drug categories, organs or systems involved in ADR, clinical manifestations, etc. RESULTS： Among 1 056 ADR cases, the number of the patients over the age of 60 was the highest （355 cases, 33.62%）; the largest number of ADR reports was caused by intravenous injection（986 cases, 93.37%）; ADR reports were most likely caused by anti-infective drugs （434 cases, 41.10% ）, followed by TCM injections （288 cases, 27.27% ） ; the main types of ADR were lesion of skin and its appendents （460 cases, 43.56% ）. CONCLUSIONS： We should pay more atten tion to the ADR monitoring and reporting and promote rational drug use.