| 三七总皂甙对小白鼠运动神经末梢递质释放的影响 |
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| 引用本文： | 关永源,Quastel D M J. 三七总皂甙对小白鼠运动神经末梢递质释放的影响[J]. 中国药理学通报, 1987, 0(3) |
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| 作者姓名： | 关永源 Quastel D M J |
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| 作者单位： | 中山医科大学药理教研组，Dept of Pharmacology，Faculty of Medicine，University of British Columbia 广州，Canada |
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| 摘 要： | 胞内记录神经—终板电位及微终板电位,证明三七总皂甙不影响神经末梢去极化时Ca~(2+)及Ba~(2+)的内流,对同步、非同步及自发性的量子释放均无减弱。由于Cd~(2+)能明显减弱量子释放,而PNS与nifedipine却无作用,提示胆碱能运动神经末梢上参与递质释放的Ca~(2+)通道属于N型Ca~(2+)通道。
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| 关 键 词： | 三七 总皂甙 镉离子 硝苯吡啶 钙通道 量子释放 膈(月凡) |
EFFECT OF THE TOTAL SAPONINS OF PANAX NOTOGISENG ON TRANSMITTER RELEAS AT MOUSE MOTOR NERVE TERMINAL |
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| Guan Yongyuan. EFFECT OF THE TOTAL SAPONINS OF PANAX NOTOGISENG ON TRANSMITTER RELEAS AT MOUSE MOTOR NERVE TERMINAL[J]. Chinese Pharmacological Bulletin, 1987, 0(3) |
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| Authors: | Guan Yongyuan |
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| Abstract: | The effect of the total saponins of panax notogiseng ( PNS ) on transmitter release was studied on mouse diaphragm. The Ca2+ -mediated release evoked by electric stimulation at the nerve terminal or by raised K+ level was markedly reduced by Cd2 + , but not affected by PNS & nifedipine. Also, PNS didn't change the basic frequency of mepp & the Ba2+ entry during depolarization of the terminal. C-ompared with PNS, Cd2 had a significant effect on decreasing Ba2+ entry. These results suggest that PNS can not change spontanous, synchronous or asynchronous release, the Ca2+ channel involved in the transmitter release at the mouse motor nerve terminal belongs in N type Ca2 channel. |
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| Keywords: | Panax notogiseng Total saponins Nifedipine Cad- mium Quanta release Diaphragm Calcium channel |
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