| 子宫腺肌病患者在位及异位内膜中CD146的表达 |
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| 引用本文： | 张军,周应芳.子宫腺肌病患者在位及异位内膜中CD146的表达[J].中国妇幼保健,2010,25(10). |
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| 作者姓名： | 张军 周应芳 |
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| 作者单位： | 1. 首都医科大学附属北京安贞医院妇产科
2. 北京大学第一医院妇产科,100034 |
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| 摘 要： | 目的:观察子宫腺肌病患者子宫在位及异位内膜组织CD146的表达与其微血管形成的关系,探讨子宫腺肌病患者微血管生成的变化。方法:手术切除子宫患者66例,其中子宫腺肌病40例(AM组),对照组26例。用免疫组织化学方法检测正常子宫内膜、腺肌病患者在位及异位内膜组织中CD146的表达及微血管数目和密度(MVD)值。结果:AM组在位内膜中MVD分泌期(33.7±4.9)明显高于增殖期(27.2±5.0)(P0.01),对照组子宫内膜中MVD分泌期(20.5±3.8)与增生期(17.9±3.6)比较差异无统计学意义(P0.05)。AM组与对照组相比无论是增殖期、分泌期及整个月经周期,在位内膜MVD均明显高于对照组内膜(P0.01)。AM组患者在位内膜(4.1±1.4)与异位内膜(4.9±1.4)CD146表达评分比较差异有统计学意义(P0.05),与在位内膜增殖期CD146表达评分(3.6±1.7)相比差异显著,与分泌期(4.7±0.6)相比评分增加,但差异无统计学意义(P0.05);而与对照组内膜整个月经周期(2.4±0.8)及增殖期(2.4±0.7)、分泌期(2.3±0.9)相比CD146表达评分均明显增加,CD146在AM患者在位内膜85%(34/40)、异位内膜90%(36/40)及对照组内膜62%(16/26)的表达阳性率与对照组相比差异有统计学意义(P0.01)。CD146与MVD具有明显的正相关性(r=0.567,P0.01)。结论:腺肌病患者子宫内膜和异位内膜CD146表达显著增强,提示CD146在子宫内膜异位症微血管形成过程中发挥了重要作用。
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| 关 键 词： | 子宫腺肌症 CD146 微血管密度 免疫组化 |
Expression of CD146 in ectopic and eutopic endometrium of patients with adenomyosis |
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| ZHANG Jun,ZHOU Ying-Fang.Expression of CD146 in ectopic and eutopic endometrium of patients with adenomyosis[J].Maternal and Child Health Care of China,2010,25(10). |
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| Authors: | ZHANG Jun ZHOU Ying-Fang |
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| Institution: | ZHANG Jun,ZHOU Ying-Fang.Department of Obstetrics , Gynecology,the First Hospital of Beijing University,Beijing 100034,China |
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| Abstract: | Objective:To observe the relationship between expression levels of CD146 in ectopic and eutopic endometrium of patients with adenomyosis and angiogenesis of microvessels,explore the changes of angiogenesis of microvessels in patients with adenomyosis.Methods:66 patients undergoing hysterectomy were divided into adenomyosis group (40 cases) and control group (26 cases),the expression levels of CD146,amount of microvessels and the values of microvessel density (MVD) in ectopic and eutopic endometrium of patie... |
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| Keywords: | Adenomyosis CD146 Microvessel density Immunohistochemistry |
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