腹腔镜下结直肠癌根治术后吻合口瘘危险因素分析

目的 探讨腹腔镜下结直肠癌根治术后吻合口瘘发生的危险因素,为吻合口瘘的防治提供依据.方法 回顾性分析 2004 年 3 月至 2013 年 4 月 42 例腹腔镜下结直肠癌根治术患者的临床资料,根据术后是否出现吻合口瘘将患者分为吻合瘘组和未发生瘘组,采用单因素和多因素分析方法探讨腹腔镜下结直肠癌根治术后吻合口瘘发生的危险因素.结果 42 例中 5 例出现吻合口瘘,发生率为11.9%.单因素分析显示吻合瘘组和未发生瘘组比较：年龄、体重指数、糖尿病、术前新辅助化疗、术前肠梗阻、肿瘤距肛门缘距离、血浆白蛋白水平差异有统计学意义（ P ＜ 0.05 ）.Logistic 多因素回归分析结果显示：年龄、糖尿病、术前新辅助化疗、术前肠梗阻、肿瘤距肛门缘距离为腹腔镜下结直肠癌根治术后发生吻合口瘘的独立危险因素.结论 腹腔镜下结直肠癌根治术后吻合口瘘的发生与年龄、糖尿病、术前新辅助化疗、术前肠梗阻、肿瘤距肛门缘距离等多个因素有关.

Analysis of the risk factors of anastomotic leakage following laparoscopic radical prostatectomy of colorectal cancer

Objective To investigate the risk factors of anastomotic leakage following laparoscopic radical prostatectomy of colorectal cancer,in order to benefit the prevention and treatment of anastomotic leakage. Methods From March 2004 to April 2013, the clinical information of 42 patients who underwent laparoscopic radical prostatectomy of colorectal cancer was collected. The patients were divided into anastomotic leakage group and non- anastomotic leakage group according to whether anastomotic leakage occured after operation. In order to determine the risk factors of anastomotic leakage following laparoscopic radical prostatectom of colorectal cancer, univariate analysis and multivariate analysis were used. Results 5 of 42 （11.9%） patients had postoperative anastomotic leakage. Comparing the two groups,univariate analysis revealed that dvanced age, body mass index, diabetes, preoperative neoadjuvant chemotherapy, preoperative intestinal obstruction, cancer distance from anus,albumin levels were in statistical significance （P 〈 0.05）. Logistic multivariate regression analysis showed that advanced age, diabetes, preoperative neoadjuvant chemotherapy, preoperative intestinal obstruction,cancer distance from anus were independent risk factors of anastomotic leakage following laparoscopic radical prostatectomy of colorectal cancer. Conclusions Risk factors such as advanced age, diabetes, preoperative neoadjuvant chemotherapy, preoperative intestinal obstruction,cancer distance from anus are related to anastomotic leakage following laparoscopic radical prostatectomy of colorectal cancer.