| APP17肽对缺氧缺血性脑病新生鼠皮质区GAP-43表达的影响 |
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| 引用本文： | 李慧玲,梅梅,刘园园,刘冬焱,顾镜月.APP17肽对缺氧缺血性脑病新生鼠皮质区GAP-43表达的影响[J].黑龙江医药科学,2009,32(3):14-15. |
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| 作者姓名： | 李慧玲 梅梅 刘园园 刘冬焱 顾镜月 |
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| 作者单位： | 佳木斯大学第一附属医院儿一科,黑龙江,佳木斯,154003 |
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| 摘 要： | 目的：观察APP（β—amyloid precursop protein，APP）17肽（APP695—319—335）肽段对缺氧缺血性脑病新生鼠皮质区GAP-43表达的影响。方法：将生后7d的新生大鼠随机分为假手术组、脑病组和APP17肽治疗组。采用一侧颈动脉结扎，然后放在缺氧仓内2h的方法制备缺氧缺血性脑病模型。应用免疫组化方法观察各组大鼠不同时期脑皮质GAP-43表达的变化。结果：免疫组化结果显示，脑病组较假手术组小鼠皮质区GAP-43免疫阳性细胞增加（P〈0．01）．治疗组较脑病组GAP-43免疫阳性细胞明显增多（P〈0．01）。结论：缺氧缺血性脑损伤后，皮质区GAP-43表达和合成增加，GAP-43的表达增加可能与神经元再生和轴突重塑有关，是脑缺氧缺血后神经细胞内源性代偿机制之一。APP17肽可能通过调节GAP-43的表达来增加神经细胞之间的突触联系，促进神经的生长起到营养神经的作用，从而改善缺氧缺血性脑病小鼠的预后。
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| 关 键 词： | 缺氧缺血性脑病 皮质 神经生长相关蛋白-43 神经营养 突触 |
Effects of APP17-mer peptide on expression of GAP-43 in the cortical area of hypoxic ischemic encephalopathy rats |
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| LI Hui-ling,MEI Mei,LIU Yuan-yuan,LIU Dong-yan,GU Jing-yue.Effects of APP17-mer peptide on expression of GAP-43 in the cortical area of hypoxic ischemic encephalopathy rats[J].Heilongjiang Medicine and Pharmacy,2009,32(3):14-15. |
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| Authors: | LI Hui-ling MEI Mei LIU Yuan-yuan LIU Dong-yan GU Jing-yue |
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| Institution: | The First Affiliated Hospital of Jiamusi University;Jiamusi 154003;China |
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| Abstract: | Objective: To study the effects of APP17-mer peptide on the expression of GAP-43 in the cortical area of hypoxic ischemic encephalopathy rats.Methods:The Wistar rats,aged 7 days,were devided into Sham-operation group,operation group and APP17 group,respectively.HIBD model was formed by adopting the permanent occlusion of one side common carotid artery in Wistar rat,and then put them into a utensil for 2 hours.The GAP-43 expression was assayed by immunohistochemical staining.Results:In hypoxic ischemic encep... |
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| Keywords: | hypoxic ischemic encephalopathy cortical area growth-associated protein-43 nutrition of nerve synapse |
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