Effect of plant melanin pigment on the clastogenic effects of chemical mutagens in mice |
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| Authors: | Alekseeva T N Durnev A D Kulakova A V Oreshchenko A V Samusenok L V Ogarkov B N Seredenin S B |
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| Institution: | Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia. |
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| Abstract: | The chromosome aberration assay in the bone marrow cells of C57BL/6 mice showed that melanin pigment (MP) in a dose range from 0.01 to 10 mg/kg does not influence the clastogenic effect of dioxidine (200 mg/kg, i.p.), while reducing the clastogenic effect of cyclophosphamide (20 mg/kg, i.p.) by a factor of 1.5-4 in various treatment regimes depending on the mutagen injection time. |
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