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The involvement of Lyt-2 antigens in the lysis of virus-infected target cells by antigen specific anti-vesicular stomatitis virus cytotoxic T-lymphocytes |
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| Authors: | A H Hale |
| Affiliation: | Department of Microbiology and Immunology, The Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27103,U.S.A. |
| Abstract: | The involvement of cell surface components associated with anti-viral cytotoxic T-lymphocytes (CTLs) in the specific lysis of virus-infected target cells was analyzed by the ability of different monoclonal antibodies to specifically inhibit CTL lytic activity. Utilizing monoclonal anti-Lyt antibodies, we showed that Lyt-2 antigens are closely associated with the CTL lytic event. The nature and limitations of this association are discussed. |
| Keywords: | CTL cytotoxic thymus-derived lymphocyte, C, complement i.p. intraperitoneal MHC major histocompatibility complex MOI multiplicity of infection NRS normal rat serum PBS phosphate-buffered saline (0.15 M NaCl, 0.01 mM potassium phosphate, pH 7.4) SDS-PAGE sodium dodecyl sulfate polyacrylamide gel electrophoresis VSV vesicular stomatitis virus |
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