| 糖尿病肾病患者血清同型半胱氨酸与血浆血小板颗粒膜蛋白140水平的变化 |
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| 引用本文： | 王瑞雪,魏剑芬,蔡庆燕,程燕,陈冬.糖尿病肾病患者血清同型半胱氨酸与血浆血小板颗粒膜蛋白140水平的变化[J].新医学,2011,42(10):645-647. |
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| 作者姓名： | 王瑞雪 魏剑芬 蔡庆燕 程燕 陈冬 |
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| 作者单位： | 1. 河北联合大学基础医学院,063009
2. 河北联合大学附属医院,063000 |
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| 摘 要： | 目的：观察不同阶段糖尿病肾病（DN）患者血清同型半胱氨酸（Hcy）与血浆血小板颗粒膜蛋白140（GMP-140）的变化及相关性。方法：150例2型糖尿病患者按照尿白蛋白水平分为正常蛋白尿组、微量白蛋白尿组及临床蛋白尿组各50例,另设50名健康对照者。检测各组血清Hcy、血浆GMP-140水平。结果：糖尿病患者血清Hcy、血浆GMP-140水平均高于对照组（P均〈0.01）;微量白蛋白尿组及临床白蛋白尿组均高于正常白蛋白尿组（P均〈0.01）;血清Hcy水平与血浆GMP-140水平呈正相关（r=0.78,P〈0.05）。结论：DN患者血清同型半胱氨酸与血浆血小板颗粒膜蛋白140水平均升高,两者具相关性。
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| 关 键 词： | 糖尿病 糖尿病肾病 同型半胱氨酸 血小板颗粒膜蛋白140 |
Changes of serum homocysteine and plasma platelet granule membrane protein 140 in type 2 diabetic ne phropathy |
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| WANG Rui-xue,WEI Jian-fen,CAI Qing-yan,CHENG Yan,CHEN Dong.Changes of serum homocysteine and plasma platelet granule membrane protein 140 in type 2 diabetic ne phropathy[J].New Chinese Medicine,2011,42(10):645-647. |
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| Authors: | WANG Rui-xue WEI Jian-fen CAI Qing-yan CHENG Yan CHEN Dong |
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| Institution: | WANG Rui-xue1,WEI Jian-fen2,CAI Qing-yan1,CHENG Yan2,CHEN Dong2.1 Hebei Union University,2 The Hospital of Hebei Union University,Tangshan 063000,China |
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| Abstract: | Objective:To investigate the changes and the relationship of serum homocysteine and platelet granule membrane protein 140 in patients with diabetic nephropathy(DN).Methods: Fifty cases of healthy persons were enrolled as the control group.One hundred and fifty cases with type 2 diabetes mellitus were divided into three groups,including normal albuminuria group,microalbuminuria group and clinical proteinuria group,each containing 50 cases.Their serum levels of homocysteine and plasma platelet granule membran... |
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| Keywords: | Type 2 diabetic mellitus Diabetic Nephropathy Homocysteine Platelet granule membrane protein 140 |
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