| 川崎病患儿血清胱抑素C的变化及其与冠状动脉病变的关系 |
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| 引用本文： | 姜毅,李温慈,徐海滨,邵山鹰. 川崎病患儿血清胱抑素C的变化及其与冠状动脉病变的关系[J]. 新医学, 2011, 42(10): 638-639,660. DOI: 10.3969/g.issn.0253-9802.2011.10.005 |
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| 作者姓名： | 姜毅 李温慈 徐海滨 邵山鹰 |
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| 作者单位： | 1. 浙江温州医学院硕士研究生,325000;浙江温州市儿童医院儿科,325027
2. 浙江温州市儿童医院儿科,325027 |
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| 摘 要： | 目的：观察胱抑素C在川崎病患儿血清中的变化及与川崎病患儿冠状动脉病变的关系。方法：选取温州市儿童医院42例川崎病和21例发热1周以内的呼吸道感染（对照组）患儿,川崎病患儿在急性期、亚急性期、恢复期接受血清胱抑素C检测,并通过心脏彩色多谱勒超声检查明确患儿冠状动脉病变情况。对照组入院后检测血清胱抑素C水平。结果：川崎病患儿在急性期和亚急性期血清胱抑素C水平均较对照组明显下降（P〈0.05）,而且冠状动脉病变组较无冠状动脉病变组下降更为显著,恢复期血清胱抑素C水平与对照组比较差异无统计学意义（P〉0.05）。结论：血清胱抑素C水平在川崎病急性期,尤其在冠状动脉病变时明显下降,亚急性期和恢复期持续不升可能与川崎病发生冠状动脉损伤程度有关,故监测胱抑素C水平可作为预测患儿冠状动脉病变的重要参考指标。
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| 关 键 词： | 川崎病 胱抑素C 冠状动脉 |
Changes of serum cystatin C in children with Kawasaki disease and its role in the pathogenesis of coronary artery lesions |
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| JIANG Yi,LI Wen-ci,XU Hai-bin,SHAO Shan-ying. Changes of serum cystatin C in children with Kawasaki disease and its role in the pathogenesis of coronary artery lesions[J]. New Chinese Medicine, 2011, 42(10): 638-639,660. DOI: 10.3969/g.issn.0253-9802.2011.10.005 |
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| Authors: | JIANG Yi LI Wen-ci XU Hai-bin SHAO Shan-ying |
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| Affiliation: | 1 Wenzhou Medical College,Wenzhou 325000,China;2 Department of Pediatrics,Children′s Hospital of Wenzhou,Wenzhou 325027,China |
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| Abstract: | Objective:To investigate the changes of serum cystatin C in children with Kawasaki disease and its role in the pathogenesis of coronary artery lesions.Methods:Fourty two children with Kawasaki disease and 21 febrile controls were studied.The duration of Kawasaki disease was divided into three phases,including the acute phase,the subacute phase and the convalescent phase.Serum cystatin C was detected by immunoturbidimetry in three phases,respectively.The coronary artery lesions were checked by doppler echoca... |
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| Keywords: | Kawasaki disease Serum cystatin C Coronary artery |
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