Notch在血液肿瘤细胞周期阻滞中的作用

细胞周期调控依赖多种调控蛋白协同作用以及生长因子等细胞外因素通过信号转导调控。这中间任一环节异常都可能引起细胞周期阻滞。p53、p21以及p16基因使细胞停滞在G1期的研究已相当透彻。Notch信号传递途径在胚胎发育和肿瘤血管发生中扮演重要的角色,尚有抑制Notch达到抑制肿瘤细胞增长的目的。新近研究发现,由配体刺激的Notch活化调节了急慢性髓细胞白血病细胞增长,Notch系统对白血病的治疗是一个很有前景的途径。

The Role of Notch in the Blood Tumor Cell Cycle Arrest

The regulation of cell cycle rely on a variety of regulatory proteins synergies and external factors such as growth factors cellular through the signal transduction and control.Any abnormalities may cause cell cycle arrest in the middle of the line.Researches showed that p53,p21,and p16 gene causes cells in the G1 phase of stagnation have been quite clear.Notch signaling pathway in embryonic development and tumor angiogenesis play an important role,and it can inhibit the tumor cell growth by inhibiting Notc...