Neuregulin is associated with nerve regeneration in axonal neuropathies |
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Authors: | Oka N Kawasaki T Matsui M Tachibana H Sugita M Akiguchi I |
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Affiliation: | Department of Neurology, Graduate School of Medicine, Kyoto University, Japan. |
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Abstract: | Neuregulins (NRG), the only trophic factors known to support Schwann cell survival, have a potential for use in treatment of patients with chronic neuropathies. Expression of one NRG isoform, NRG-beta1, was increased in axons in the early phase of axonal degeneration in nerve biopsy specimens from patients with neuropathy. Regenerating nerve fibers contained abundant NRG-beta1 in axons, but nerves from patients with chronic axonal neuropathy showed less. NRG-beta1 may act as an axonally derived signal having a trophic effect on denervated Schwann cells, facilitating their supportive role in axonal regeneration. |
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