姜黄素对大鼠心肌缺血再灌注损伤的保护作用

目的观察姜黄素对大鼠心肌缺血再灌注损伤的保护作用。方法结扎大鼠冠状动脉左前降支,使心肌缺血60m in,再灌注30 m in,制成急性心肌缺血再灌注损伤模型,缺血前5 m in,舌下静脉推注姜黄素,观察在急性缺血和再灌注状态下血流动力学的变化。再灌注结束时测量心肌梗死面积。结果姜黄素(20,40 mg.kg-1)能剂量依赖地改善大鼠心肌缺血再灌注后的血流动力学变化,LVSP、±dp/dtm ax均较缺血再灌注对照组升高,LVEDP有所降低;同时可减少心肌梗死面积。结论姜黄素对心肌缺血再灌注损伤有保护作用。

Protective effects of curcumin on myocardial ischemia reperfusion injury in rats

Aim To study the protective effects of curcumin on myocardial reperfusion injury in rats.Methods Myocardial ischemia reperfusion injury model was established through occluding the left anterior descending branch of coronary artery for 60 min and removing the ligation later to reperfuse for 30 min in vivo.Different doses of curcumin were administered through intravenous injection 5 min before the onset of ischemia.The changes of hemodynamics were recorded and myocardial infarct sizes were measured.Results Curcumin(20,40 mg·kg~(-1))improved the hemodynamics during myocardial ischemia reperfusion in a dose-dependent manner,as shown by the significant increase in LVSP and±dp/dt_(max) and the decrease in LVEP.Moreover,curcumin reduced the myocardial infarct sizes.Conclusion Curcumin exerts protective effects on myocardial ischemia reperfusion injury.