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Familial aggregation of age-related macular degeneration in the Utah population
Authors:Luo Ling  Harmon Jennifer  Yang Xian  Chen Haoyu  Patel Shrena  Mineau Geraldine  Yang Zhenglin  Constantine Ryan  Buehler Jeanette  Kaminoh Yuuki  Ma Xiang  Wong Tien Y  Zhang Maonian  Zhang Kang
Affiliation:Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Abstract:We examined familial aggregation and risk of age-related macular degeneration in the Utah population using a population-based case-control study. Over one million unique patient records were searched within the University of Utah Health Sciences Center and the Utah Population Database (UPDB), identifying 4764 patients with AMD. Specialized kinship analysis software was used to test for familial aggregation of disease, estimate the magnitude of familial risks, and identify families at high risk for disease. The population-attributable risk (PAR) for AMD was calculated to be 0.34. Recurrence risks in relatives indicate increased relative risks in siblings (2.95), first cousins (1.29), second cousins (1.13), and parents (5.66) of affected cases. There were 16 extended large families with AMD identified for potential use in genetic studies. Each family had five or more living affected members. The familial aggregation of AMD shown in this study exemplifies the merit of the UPDB and supports recent research demonstrating significant genetic contribution to disease development and progression.
Keywords:Age-related macular degeneration   Genetic epidemiology   Genetics
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