肠道病毒性脑膜炎的病原学研究

本告从23例临床上诊断为病毒性脑膜炎患者的脑脊液、血液中分离出柯萨奇B组病毒2株,未定型病毒1株,用所分离到的病毒与该患者恢复期血清做中和抗体测定均4倍或4倍以上升高,可以确定分离出的病毒与脑膜炎患者是相关的。同时检测57例脑膜炎患者恢复期血清中的柯萨奇B组病毒中和抗体,4倍或4倍以上升高者19例(33.3％)。40例健康人血清中柯萨奇B组病毒抗体阳性的(1:64)1例,两者差异显著(P<0.01)。结果表明,测定恢复期血清中和抗体结合临床对肠道病毒性脑膜炎的病因学诊断有一定的参考价值。

ETIOLOGIC STUDY ON ENTEROVIRAL MENINGITIS

Three strains of viruses including Coxsakie B3,B6and undetermined type were gisolated from the cerebrospinal fluid and blood of 23 patients with viral meningitis diagnosed clinically.The relationship between the isolated viruses and the disease was determined by neutralization test of paired sera of the patients to viruses isolated from patients themselves.At the same time the neutral antibodies against Coxsakie B viruses in sera of 57 patients with viral meningitis and 40 healthy people were detected.The titer of antibodies in 19/57 sera during the convalescent stage were 4 times higher than that during the acute stage (33.3%) , and the titer of antibodies in 1/40 was 1 :64 (2.5%) .The difference between the disease dand the control groups was significant (P<0.01) . The results showed that the combined method of detection of neutral antibodies and the clinical practice was of referential value to etiological diagnosis of viral meningitis.