普罗布考预防老年冠心病患者经皮冠状动脉介入治疗后再狭窄的临床观察

目的　观察抗氧化剂普罗布考预防老年冠心病患者经皮冠状动脉介入治疗 (PCI)后再狭窄的临床效果。方法　 6 2例患者随机分为普罗布考组 (32例 )和对照组 (30例 )。观察PCI前、后及随访 6个月冠状动脉造影、血清氧化指标氧化型低密度脂蛋白、丙二醛和内皮指标一氧化氮、内皮素变化情况。结果　随访 6个月时普罗布考组最小管腔直径和管腔净获得较对照组明显增加 (2 .2± 0 .7)mmvs (l.4± 0 .3)mm ,P <0 .0 5 ;(1.8± 0 .4 )mmvs(0 .9± 0 .2 )mm ,P <0 .0 1) ],再狭窄率明显下降 (2 0 .2 %vs4 0 .0 % ,P <0 .0 5 ) ;血清氧化型低密度脂蛋白和丙二醛较对照组明显减少 (0 .381± 0 .0 8)mg Lvs(0 .70 5± 0 .16 )mg L ,P <0 .0 1;(6 .2 0± 0 .5 7)nmol Lvs(l8.6 2± 2 .13)nmol L ,P <0 .0 1) ]。结论　抗氧化剂普罗布考可以降低PCI后 6个月冠状动脉再狭窄的发生率。

Preventive effect of probucol on restenosis after percutaneous coronary intervention in the aged

Objective To investigate the effectiveness of antioxidant probucol therapy in the prevention of restenosis in senile patients after percutaneous coronary intervention(PCI).Methods Sixty-two patients were randomly assigned to probucol group(32 cases) and control(30 cases).Effects of probucol on the minimal lumen diameter, luminal net gain and restenosis rate of dilated coronary arteries were observed through coronary angiography.Serum oxLDL, MDA, NO and ET levels were determined before PCI and six months after PCI.Results At follow-up angiography six months after PCI,it was found that the minimal lumen diameter and lumimal net gain were significantly increased in probucol group as compared with those in control(2.2±0.7) mm vs (1.4±0.3) mm, P<0.05;(1.8± 0.4) mm vs (0.9±0.2) mm, P<0.0l, respectively],and restenosis rate was markedly reduced to 20.2% in probucol group as compared with 40.0% in control (P< 0.05). Serum levels of oxLDL and MDA in probucol group were significantly lower than those in control ( 0.381±0.08) mg/L vs (0.705±0.16) mg/L, P<0.01;(6.20±0.57) nmol/L vs (18.62±2.13) nmol/L, P<0.01,respectively].Conclusion Antioxidant probucol is able to reduce restenosis rate six months after PCI.