An experimental paradigm for studying the discriminative stimulus properties of drugs in humans |
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Authors: | L D Chait E H Uhlenhuth C E Johanson |
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Institution: | (1) Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago Drug Abuse Research Center, 60637 Chicago, IL, USA |
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Abstract: | An experimental paradigm for studying the discriminative stimulus effects of drugs in human subjects is presented. The paradigm was tested by training subjects to discriminate 10 mg d-amphetamine from placebo. Subjects who successfully learned the discrimination were then tested with two lower doses of d-amphetamine and with 10 mg diazepam. The discriminative stimulus properties of d-amphetamine were dose-dependent, and in two of five subjects the d-amphetamine stimulus generalized to diazepam. The simplicity and versatility of the paradigm give it the potential for use in a wide variety of experimental and clinical situations. |
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Keywords: | Drug discrimination Human d-Amphetamine |
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