| 重组人粒细胞集落刺激因子对辐射后小鼠中性粒细胞减少的治疗作用 |
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| 关 键 词： | 中性粒细胞减少症 重组人粒细胞集落刺激因子 钴放射性同位素类 辐射 小鼠 药理作用 |
Therapeutic effect of the recombinant human granulocyto colony-stiimulating factor on radiation-induced agranulocytosis models of mice] |
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| Hong Zhu,Fu-ying Lai,Li Sun. Therapeutic effect of the recombinant human granulocyto colony-stiimulating factor on radiation-induced agranulocytosis models of mice][J]. Bulletin of Hunan Medical University, 2002, 27(6): 509-511 |
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| Authors: | Hong Zhu Fu-ying Lai Li Sun |
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| Affiliation: | Department of Radiotherapy, Xiangya Hospital, Central South University, Changsha 410008, China. |
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| Abstract: | OBJECTIVE: To observe the effect of the recombinant human granulocyto colony-stimulating factor (rhG-CSF) on radiation-induced neutropenia models of mice. METHODS: rhG-CSF in 2 different doses (10 micrograms.kg-1.d-1 and 30 micrograms.kg-1.d-1) was injected respectively to radiation-induced neutropenia models of mice. The effect of rhG-CSF on the weight of the spleen, CFU-S, leukocyte counts, neutrophil counts, and CFU-GM of the marrow cell culture was observed. RESULTS: Both 30 and 10 micrograms.kg-1.d-1 of rhG-CSF increased CFU-GM of the marrow cell culture and the peripheral leukocyte and neutrophil, showing a significant difference compared with the NS control group (P < 0.05). CONCLUSION: rhG-CSF has a significant therapeutic effect on radiation-induced agranulocytosis models of mice. |
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