| 膀胱癌多药耐药性的检测及其意义 |
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| 引用本文： | Kang XL,Geng ZH,Lu XX,Wei C,Wang JG,Wang SZ,Ma S,Liu HX,Xu GY,Zhang HW,Wang GY. 膀胱癌多药耐药性的检测及其意义[J]. 中华外科杂志, 2004, 42(5): 285-287 |
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| 作者姓名： | Kang XL Geng ZH Lu XX Wei C Wang JG Wang SZ Ma S Liu HX Xu GY Zhang HW Wang GY |
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| 作者单位： | 1. 257055,山东省东营市,中国石化集团胜利医院泌尿外科
2. 257055,山东省东营市,中国石化集团胜利医院病理科 |
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| 摘 要： | 目的探讨膀胱癌的多药耐药性(MDR)以指导灌注化疗用药。方法采用免疫组化法检测44例膀胱癌病理标本,分析P-糖蛋白(P-gp)、谷胱甘肽S转移酶(GST-π)和拓扑异构酶(TOPO-Ⅱ)的表达情况。结果54．5％的病例P-gP高表达;65．9％的病例GST-π无表达和低表达;TOPO-Ⅱ,高表达29．5％,而低表达65．9％。结论检测膀胱癌MDR可指导灌注化疗用药。
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| 关 键 词： | 膀胱癌 多药耐药性 检测 治疗 |
Detecting multi-drug resistance of bladder cancer for the intravesical chemotherapy |
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| Kang Xin-li,Geng Zhen-hong,Lu Xing-xiang,Wei Chao,Wang Jin-gang,Wang San-zhong,Ma Sen,Liu Hong-xin,Xu Guo-ying,Zhang Hua-wei,Wang Guo-yong. Detecting multi-drug resistance of bladder cancer for the intravesical chemotherapy[J]. Chinese Journal of Surgery, 2004, 42(5): 285-287 |
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| Authors: | Kang Xin-li Geng Zhen-hong Lu Xing-xiang Wei Chao Wang Jin-gang Wang San-zhong Ma Sen Liu Hong-xin Xu Guo-ying Zhang Hua-wei Wang Guo-yong |
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| Affiliation: | Department of Urology, Shengli Hospital, Shandong 257055, China. |
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| Abstract: | OBJECTIVE: To explore multi-drug resistance (MDR) of bladder cancer for the intravesical instillation. METHODS: Using immunohistochemical staining, in 44-case human bladder cancer cells, the expressions of P-glycoprotein (P-gp), glutathione S-transferase (GST-pi) and topoisomerase (TOPO-II), were detected to find out the resistance to drugs. RESULTS: P-gp had a higher expression in 54.5% cases. GST-pi had no or a lower expression in 65.9% cases. TOPO-II had a higher expression in 29.5% but a lower expression in 65.9% cases. CONCLUSION: Detecting the factors of MDR in bladder cancer cells could help to choose drugs for intravesical chemotherapy. |
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| Keywords: | Bladder cancer Multi-drug resistanc P-glyprotein Glutathione-S-transferase Topoisomerase |
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