Lack of effect of baclofen on substance P and somatostatin release from the spinal cord in vitro |
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| Authors: | J. Sawynok N. Kato V. Havlicek F. S. LaBella |
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| Affiliation: | (1) Departments of Pharmacology and Therapeutics and Physiology, University of Manitoba, R3E OW3 Winnipeg, Manitoba, Canada;(2) Department of Pharmacology, Dalhousie University, B3H 4H7 Halifax, Nova Scotia, Canada |
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| Abstract: | Summary High concentrations of K+ increase the release of substance P (SP) and somatostatin (SRIF) from superfused slices of rat spinal cord. This increase is Ca-dependent. Baclofen (100–500  M) does not significantly alter the K+-evoked release of SP or SRIF. Stereoisomers of baclofen and GABA, similarly, are without effect. The spinal analgesic action of baclofen does not appear to be due to alterations in the release of SP or SRIF. |
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| Keywords: | Baclofen Substance P Somatostatin Spinal cord Release |
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