Association of baseline vitamin D level with genetic determinants and virologic response in patients with chronic hepatitis B |
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| Authors: | Rui Yu Deming Tan Qin Ning Junqi Niu Xuefan Bai Shijun Chen Jun Cheng Yanyan Yu Hao Wang Min Xu Guangfeng Shi Mobin Wan Xinyue Chen Hong Tang Jifang Sheng Xiaoguang Dou Junping Shi Hong Ren Maorong Wang Hongfei Zhang Zhiliang Gao Chengwei Chen Hong Ma Jidong Jia Jinlin Hou Qing Xie Jian Sun |
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| Institution: | 1. Department of Infectious Diseases, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang Hospital, Southern Medical University, Guangzhou, China;2. Department of Digestive Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;3. Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, China;4. Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;5. Hepatology Unit, No. 1 Hospital affiliated to Jilin University, Changchun, China;6. Department of Infectious Diseases, Tangdu Hospital, Xi'an, China;7. Ji'nan Infectious Diseases Hospital, Ji'nan, China;8. Beijing Ditan Hospital, Beijing, China;9. Department of Infectious Diseases, First Hospital of Peking University, Beijing, China;10. Hepatology Unit, Peking University People's Hospital, Beijing, China;11. 8th People's Hospital, Guangzhou, China;12. Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China;13. Department of Infectious Diseases, Changhai Hospital, Shanghai, China;14. Beijing Youan Hospital, Beijing, China;15. Department of Infectious Diseases, West China Hospital, Chengdu, China;16. Department of Infectious Diseases, Zhejiang University 1st Affiliated Hospital, Hangzhou, China;17. Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, China;18. 6th People's Hospital, Hangzhou, China;19. Department of Infectious Diseases, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China;20. Department of Infectious Diseases, 81st PLA Hospital, Nanjing, China;21. 302nd PLA Hospital, Beijing, China;22. Department of Infectious Diseases, Sun Yat‐Sen University 3rd Affiliated Hospital, Guangzhou, China;23. Department of Infectious Diseases, 85th PLA Hospital, Shanghai, China;24. Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China;25. Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China |
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| Abstract: | Aim The role of vitamin D in individuals with chronic hepatitis B (CHB) is unclear. We aimed to explore the association of baseline vitamin D level with genetic determinants and week‐104 treatment outcome in CHB patients. Methods Baseline serum 25‐hydroxycholecalciferol (25(OH)D) levels and genetic polymorphism within GC, DHCR7, and CYP2R1 were determined in stored serum of 560 patients who were enrolled into a multicenter, randomized, controlled study and completed 104 weeks of telbivudine monotherapy or telbivudine‐based optimized therapy. Virologic response was defined as hepatitis B virus DNA <300 copies/mL (52 IU/mL) at week 104. Results The mean 25(OH)D value was 29.64 ng/mL. The percentage of patients with vitamin D insufficiency (<30 ng/mL) and vitamin D deficiency (<20 ng/mL) were 55.0% and 20.9%, respectively. Gender, season, latitude, and GC rs2282679 polymorphism were independent factors of vitamin D status. Patients with sufficient vitamin D (≥30 ng/mL) achieved a higher virologic response rate than those with vitamin D insufficiency (81.7% vs. 67.2%, P < 0.001). The area under the curve of 25(OH)D to predict virologic response was 0.65 (P < 0.001; 95% confidence interval, 0.62–0.67). On multivariate analysis, 25(OH)D level was an independent predictor of virologic response, but not associated with hepatitis B envelope antigen (HBeAg) seroconversion or alanine aminotransferase (ALT) normalization. Conclusions Vitamin D insufficiency was highly prevalent in treatment‐naïve CHB patients in mainland China. Latitude and genetic determinants affect vitamin D status. Baseline vitamin D level can predict week‐104 virologic response, but not HBeAg seroconversion or ALT normalization. |
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| Keywords: | genetic determinants hepatitis B latitude treatment response vitamin D |
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