High-calorie parenteral alimentation: serum lactic and pyruvic acid levels in immature dogs during infusion with concentrated glucose solutions

Solutions of glucose of varying concentrations (10%–25%) were administered through central venous catheters to immature dogs in volumes greater than those employed in clinical total parenteral infusion therapy. Blood lactate and pyruvate levels were not raised during the course of the infusion, irrespective of the glucose concentration employed. Acidosis was not produced by these infusions. Glucose concentrations of approximately 20% were utilized most effectively, as demonstrated by total glucose retention. Clinical lactic acidemia is probably not adversely affected by continued infusion of high concentrations of glucose.