血浆同型半胱氨酸水平与脑梗死和脑溢血的关系

目的:测定脑梗死和脑溢血患者及正常对照者血浆同型半胱氨酸(HCY)、叶酸(Fa)、维生素B12 (VitB12),探讨其浓度对脑梗死和脑溢血的影响关系。方法:正常对照者来自本院体检,脑梗死及脑溢血患者, 经头颅CT或MRI确诊,用荧光偏振免疫技术(FPIA)分析血浆同型半胱氨酸和用免疫荧光技术检测Fa、 VitB12。结果:脑梗死和脑溢血患者的HCY均高于对照组,与对照组存在着非常显著性差异(P<0.01);脑梗 死和脑溢血患者的Fa、VitB12均低于对照,与对照组存在着非常显著性差异(P<0.01);脑梗死和脑溢血患者之 间三项指标无显著性差异。结论:血HCY、Fa、VitB12水平在脑梗死和脑溢血患者的病程中存在着重要的作用。

Study on Plasma Homocysteine (HCY) Levels in Patients with Cerebral Infarction and Cerebral Hemorrhage

Objective To investigate the relationship between the plasma levels of HCY, folate and vitamin B 12 and the development of cerebrovascular accidents (infarction and hemorrhage). Methods Plasma HCY concentrations (with fluorescence polarization immunoassay FPIA) and folate, VitB 12 contents (with immunofluroscence technique) were measured in 150 patients with cerebral infarction, 171 patients with cerebral hemorrhage (all patients confirmed with CT/MRI) and 96 controls. Results Plasma HCY concentrations were significantly higher (P<0.01) and plasma folate, VitB 12 contents were significantly lower (P<0.01) in all the patients than those in the controls. Differences between the values of these parameters in the patients with cerebral infarction and the patients with cerebral hemorrhage were not significant. Conclusion Plasma HCY, folate and VitB 12 concentrations were critically involved in the development and pathogenesis of cerebrovascular accidents.