Simultaneous [99mTc]TRODAT-1 and [123I]ADAM Brain SPECT in Nonhuman Primates |
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Authors: | Kuo-Hsing Ma Jong-Kang Lee San-Yuan Huang Chin-Bin Yeh Yi-Chun Shen Lie-Hang Shen Chia-Chieh Chen Ren-Shyan Liu Jiang-Chuan Liu Wen-Sheng Huang |
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Institution: | (1) Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan;(2) Department of Nuclear Medicine, Chung-Shan Medical University Hospital, Taichung, Taiwan;(3) Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan;(4) Department of Medical Imaging, Buddhist Tzu Chi Dalin General Hospital, Chiayi, Taiwan;(5) Institute of Nuclear Energy Research, Taoyaun, Taiwan;(6) Department of Nuclear Medicine, National Yang-Ming University, Taipei, Taiwan;(7) Department of Nuclear Medicine, Tri-Service General Hospital, No. 325, Cheng-Kung RD., Neihu 114, Taipei, Taiwan |
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Abstract: | Purpose This study examined the feasibility of simultaneous dopamine and serotonin transporter imaging using 123I]ADAM and 99mTc]TRODAT-1 single photon emission computed tomography (SPECT).
Procedures Simultaneous 123I]ADAM (185 MBq) and 99mTc]TRODAT-1 (740 MBq) SPECT was performed in three age-matched female Formosan rock monkeys. An asymmetric energy window was
used for dual, and symmetric energy windows were used for single-isotope imaging. Oral fluoxetine (20 mg) and intravenous
methylphenidate HCl (1 mg/kg) were given 24 h and 10 min, respectively, before dual-isotope SPECT to test imaging specificities
of 123I]ADAM and 99mTc]TRODAT-1.
Results Comparable image quality and uptake ratios between dual- and single-isotope SPECT scans were found. Dual-isotope SPECT in
fluoxetine-pretreated monkeys showed decreased uptake of 123I]-ADAM, but not of 99mTc]TRODAT-1. Dual-isotope SPECT in methylphenidate-pretreated monkeys showed decreased 99mTc]TRODAT-1 uptake without affecting 123I]-ADAM uptake.
Conclusion Simultaneous 123I]-ADAM and 99mTc]TRODAT-1 SPECT appears promising in nonhuman primates and may provide a suitable preclinical model with further clinical
implications. |
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Keywords: | Dual isotope [123I]ADAM [99mTc]TRODAT-1 SPECT |
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