Typing of the immunological system in human embryos by coelocentesis |
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Authors: | Renda Maria Concetta Makrydimas George Nicolaides Kipros H Fecarotta Emanuela Damiani Gianfranca Picciotto Francesco Jakil Maria Cristina Maggio Aurelio |
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Affiliation: | Regional Center for Thalassemia, Haematology II with Thalassemia, V. Cervello Hospital, Palermo, Italy. |
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Abstract: | Coelocentesis offers a new opportunity for gaining access to the human embryos from 28 d postfertilization. However, while some studies about its biochemical composition have been reported, our knowledge about immunological pattern of this compartment is still limited. For this reason, we studied the human coelomic fluids sampled from 6.6 to 10 wk of gestation. The majority of cellular population consisted in mesenchymal/epithelial cells. In fluids sampled before 10 wk we found only a preT Cell Receptor expression and an absence or a very low frequency of B lymphocytes, T lymphocytes and NK (natural killer) antigens. These preliminary data suggest that the immunological system in human embryos could be in the ideal conditions to start a process of tolerance induction. |
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Keywords: | fetus coelomic cavity coelocentesis TCR T lymphocytes mesenchimal cells |
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