Effect of dimethylsulfate on the structure and cytoarchitectonics of rat thymus

Changes of structure and cell ratios of different functional zones in the thymus under conditions of long-term dimethylsulfate administration at 0.1 and 2.0 mg/m³ on the organism are studied morphometrically on histological preparations from Wistar rats. Cyclic reactions of the thymus to the toxic substance are found to be due to compensatory processes. It is shown that the nature of the reaction does not depend on the concentration of toxic substance but that the extent of changes is a function of the dimethylsulfate concentration. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 1, pp. 96–100, January, 1995