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PREVENTION BY CYCLOHEXIMIDE OF THE AUDIOGENIC SEIZURES AND TRYPTOPHAN METABOLIC DISTURBANCES OF ETHANOL WITHDRAWAL IN RATS |
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| Authors: | ORETTI, ROSSANA BANO, SAMINA MORGAN, CHRISTOPHER J. BADAWY, ABDULLA A.-B. BONNER, ADRIAN BUCKLAND, PAUL McGUFFIN, PETER |
| Affiliation: | Department of Psychological Medicine, University of Wales College of Medicine Heath Park, Cardiff CF4 4XN, UK 1Cardiff Community Healthcare NHS Trust, Biomedical Research Laboratory, Whitchurch Hospital Cardiff CF4 7XB, UK 2Addictive Behaviour Centre, Roehampton Institute, Whitelands College West Hill, London SW15 3SN, UK |
| Abstract: | Cycloheximide (20 mg/kg body wt, given intraperitoneally at1 and 3 h after withdrawal of an ethanol-containing liquiddiet) prevents the activation of liver tryptophan pyrrolase,the consequent inhibition of synthesis of brain 5-hydroxytryptamine,and the audiogenic seizures observed at 7 h after alcohol withdrawal.We suggest that a rapidly-turning-over protein mediates thealcohol withdrawal syndrome and discuss the possible role ofliver tryptophan pyrrolase. |
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