联合测定孕酮及CA_(125)在预测先兆流产预后的诊断价值

目的:探讨联合测定血清孕酮及CA125在预测先兆流产预后的价值。方法:选择201例孕龄在5～12周的单胎孕妇,根据妊娠结局分为3组,正常妊娠组80例,先兆流产组68例,难免流产组53例,各组无年龄、孕产次及体重差异,测定血清孕酮及CA125水平。结果:安胎成功者孕酮水平高于流产组(P<0.05),CA125低于流产组(P<0.05)。以孕酮<16.3ng/ml为临界值,预测流产敏感性、特异性及准确性为86.2%、83.1%、85.2%,以CA125值>49.1U/ml为临界值,预测难免流产的敏感性、特异性及准确性分别为79.1%、81.2%、82.1%,如同时以孕酮<16.3ng/ml及CA125>49.1U/ml为临界值,预测难免流产的敏感性、特异性及准确性分别为78.3%、86.2%、90.1%。结论:在预测先兆流产预后的检测中,联合测定血清孕酮及CA125比单项测定指标的预测准确率明显提高。

The Value of Combine Serum Progesterone and CA125 for Forecast the Outcome of Threatened Abortion

Objective:Assess the value of combine serum progesterone and CA125 for forecast the outcome of threatened abortion.Methods:Clinical data of 201 cases of early monovular pregnancy(5~12 weeks) were analyzed and divided into three groups:normal intrauterine pregnancy group(NIUP), threatened abortion group and inevitable abortion group.Serum progesterone and CA125 level were assayed in all women.Results:The progesterone level of inevitable abortion was significantly lower than that of threatened abortion (P<0.05).On the contrary, the CA125 level of inevitable abortion was significantly higher than that of threatened abortion (P<0.05).The serum progesterone and CA125 level assay is valuable in detecting inevitable abortion.Separate serum progesterone<16.3 ng/ml and CA125>49.1 U/ml for the critical value.The sensitivity,specificity and accuracy were 86.2% 、83.1%、 85.2%and 79.1%、81.2%、82.1%,If combine serum progesterone<16.3 ng/ml and CA125>49.1 U/ml,the three rates would be 78.3%、86.2%、90.1%.Conclusion:Combine serum progesterone and CA125 level assay is more valuable than single index in forecast the outcome of threatened abortion.