| 慢性鼻-鼻窦炎小鼠模型及应用现状 |
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| 引用本文： | 王志远,张革化. 慢性鼻-鼻窦炎小鼠模型及应用现状[J]. 山东大学耳鼻喉眼学报, 2015, 29(5): 76-78. DOI: 10.6040/j.issn.1673-3770.0.2015.184 |
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| 作者姓名： | 王志远 张革化 |
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| 作者单位： | 中山大学附属第三医院耳鼻咽喉-头颈外科, 广东 广州 510630 |
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| 基金项目： | 国家自然科学基金(81371073);广州市天河区科技计划项目(201409KW027) |
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| 摘 要： | 慢性鼻-鼻窦炎(CRS)是上呼吸道常见的慢性炎症性疾病,严重影响了患者生活质量,目前其发病机制尚不明确。CRS的动物模型是研究人类CRS病理机制和疗效的理想手段。小鼠是目前CRS常用的造模动物。就小鼠CRS的造模方法、模型评价指标及模型的应用现状等做研究综述。
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| 关 键 词： | 鼻息肉 文献综述 慢性鼻-鼻窦炎 小鼠 动物模型 |
| 收稿时间： | 2015-05-10 |
Establishment and application of model of chronic rhinosinusitis in mice |
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| WANG Zhiyuan,ZHANG Gehua. Establishment and application of model of chronic rhinosinusitis in mice[J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2015, 29(5): 76-78. DOI: 10.6040/j.issn.1673-3770.0.2015.184 |
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| Authors: | WANG Zhiyuan ZHANG Gehua |
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| Affiliation: | Department of Otolaryngology & Head and Neck Surgery, Guangzhou 510630, Guangdong, China |
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| Abstract: | Chronic rhinosinusitis(CRS) is a common chronic inflammatory disease of the upper respiratory tract, which seriously affects the patients' quality of life. Because of its uncertain pathogenesis, the curative effect is not satisfactory. Animal model of CRS is the ideal means for study of the human CRS pathological mechanism and curative effect. Mice are currently common CRS animals. The main content of the review includes research progress of the mice CRS-building methods, the evaluation index and application status of the model. |
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| Keywords: | Nasal polyps Animal model Mouse Literature review Chronic rhinosinusitis |
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